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TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195589(2-amino-1,5-dihydro-7-[[(2S,4R)-2-(hydroxymethyl)-...)
Affinity DataKi:  1nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195593(2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-p...)
Affinity DataKi:  2nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195597(2-amino-1,5-dihydro-7-[[N,N-bis-[2-(hydroxy)ethyl]...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-2)
Glsynthesis

LigandPNGBDBM21885(2,9-disubstituted 6-oxopurine, 12i | 9-[4-(decahyd...)
Affinity DataKi:  5nM IC50:  13nMAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  10nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195591(2-amino-1,5-dihydro-7-[[[2-(hydroxy)ethyl]amino]me...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  20nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
Glsynthesis

LigandPNGBDBM21885(2,9-disubstituted 6-oxopurine, 12i | 9-[4-(decahyd...)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50:  150nMpH: 7.5 T: 37°CAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  30nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195595(2-amino-1,5-dihydro-7-[[[N-[2-(hydroxy)ethyl]-N-me...)
Affinity DataKi:  30.6nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase, cytosolic(Human)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM21866(2-phenylamino-9-(4-hydroxybutyl)-6-oxopurine | 9-(...)
Affinity DataKi:  50nMAssay Description:Binding affinity of the compound towards HSV-1 thymidine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  90nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  90nMAssay Description:Inhibition of HIV1 free wild type reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  100nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  110nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195588(2-amino-1,5-dihydro-7-[[N-[ethyl]-N-[2-(hydroxy)et...)
Affinity DataKi:  112nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  120nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  140nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  140nMAssay Description:Inhibition of HIV1 free reverse transcriptase V179D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  150nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  190nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  200nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  200nMAssay Description:Inhibition of HIV1 free reverse transcriptase L100I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50366681(BRIVUDINE | BVDU | Bridic | Brivox | Brivudin | Br...)
Affinity DataKi:  240nMAssay Description:Inhibition of Herpes simplex virus 1 recombinant thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50123605(CHEMBL3143935)
Affinity DataKi:  300nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195594(2-amino-1,5-dihydro-7-[[(2S)-2-(methoxymethyl)-1-p...)
Affinity DataKi:  306nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195590(2-amino-1,5-dihydro-7-[[(2S)-2-(aminomethyl)-1-pyr...)
Affinity DataKi:  306nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPurine nucleoside phosphorylase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50195596(2-amino-1,5-dihydro-7-[[(2R)-2-(hydroxymethyl)-1-p...)
Affinity DataKi:  316nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  400nMAssay Description:Inhibition of HIV1 free wild type reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  400nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  420nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  420nMAssay Description:Inhibition of HIV1 free wild type reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  510nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339536((+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)m...)
Affinity DataKi:  510nMAssay Description:Inhibition of HIV1 free reverse transcriptase K103N mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  510nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  540nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  620nMAssay Description:Inhibition of HIV1 free reverse transcriptase V179D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  620nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  700nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50123605(CHEMBL3143935)
Affinity DataKi:  700nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  700nMAssay Description:Inhibition of HIV1 free reverse transcriptase L100I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  780nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  780nMAssay Description:Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  780nMAssay Description:Inhibition of HIV1 free reverse transcriptase V179D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  1.04E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339522((+/-)-6-Ethyl-6-[4-[(4-bromophenylthio)methyl]phen...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of HIV1 free reverse transcriptase L100I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA binary complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
2-Universit£

Curated by ChEMBL
LigandPNGBDBM50339512((+/-)-6-Ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7...)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of HIV1 free reverse transcriptase K103N mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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