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LigandPNGBDBM50110039(1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM50451480(CHEMBL2093042)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50110030(1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366802(CHEMBL1788264)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128502(US8796244, 81)
Affinity DataIC50:  0.447nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128624(US8796244, 213)
Affinity DataIC50:  0.460nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128551(US8796244, 133)
Affinity DataIC50:  0.484nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128659(US8796244, 250)
Affinity DataIC50:  0.5nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128516(US8796244, 95)
Affinity DataIC50:  0.530nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128496(US8796244, 75)
Affinity DataIC50:  0.535nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128668(US8796244, 261)
Affinity DataIC50:  0.540nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128468(US8796244, 47)
Affinity DataIC50:  0.542nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128427(US8796244, 6)
Affinity DataIC50:  0.545nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128428(US8796244, 7)
Affinity DataIC50:  0.550nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128561(US8796244, 145)
Affinity DataIC50:  0.560nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128488(US8796244, 67)
Affinity DataIC50:  0.569nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128425(US8796244, 4)
Affinity DataIC50:  0.570nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128465(US8796244, 44)
Affinity DataIC50:  0.582nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128466(US8796244, 45)
Affinity DataIC50:  0.603nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128459(US8796244, 38)
Affinity DataIC50:  0.610nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128534(US8796244, 113)
Affinity DataIC50:  0.610nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128461(US8796244, 40)
Affinity DataIC50:  0.612nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128453(US8796244, 32)
Affinity DataIC50:  0.613nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128436(US8796244, 15)
Affinity DataIC50:  0.640nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128725(US8796244, 319)
Affinity DataIC50:  0.643nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128474(US8796244, 53)
Affinity DataIC50:  0.675nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128443(US8796244, 22)
Affinity DataIC50:  0.704nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128543(US8796244, 122)
Affinity DataIC50:  0.704nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128550(US8796244, 132)
Affinity DataIC50:  0.710nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128503(US8796244, 82)
Affinity DataIC50:  0.715nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128497(US8796244, 76)
Affinity DataIC50:  0.730nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128491(US8796244, 70)
Affinity DataIC50:  0.740nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128545(US8796244, 124)
Affinity DataIC50:  0.789nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128458(US8796244, 37)
Affinity DataIC50:  0.807nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128457(US8796244, 36)
Affinity DataIC50:  0.820nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128422(US8796244, 1)
Affinity DataIC50:  0.830nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128653(US8796244, 242)
Affinity DataIC50:  0.830nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128512(US8796244, 91)
Affinity DataIC50:  0.840nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128423(US8796244, 2)
Affinity DataIC50:  0.850nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128646(US8796244, 235)
Affinity DataIC50:  0.880nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128501(US8796244, 80)
Affinity DataIC50:  0.890nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128532(US8796244, 111)
Affinity DataIC50:  0.890nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128566(US8796244, 152)
Affinity DataIC50:  0.930nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128513(US8796244, 92)
Affinity DataIC50:  0.940nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128658(US8796244, 247)
Affinity DataIC50:  0.960nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128616(US8796244, 204)
Affinity DataIC50:  0.990nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM128740(US8796244, 335)
Affinity DataIC50:  0.990nMpH: 8.0 T: 25°CAssay Description:Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...More data for this Ligand-Target Pair
In DepthDetails US Patent

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