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TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434313(CHEMBL2386571)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to FAAH in human cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434313(CHEMBL2386571)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to FAAH in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195157((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-3-me...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19235(2-{5-[4-({[(2,4-difluorophenyl)methyl](3-methanesu...)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434318(CHEMBL2386566)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195151((8S,11R,13S,14S,17S)-11-(4-allyloxy-3-chloro-pheny...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195143((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-3,5-...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434329(CHEMBL2386554)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434316(CHEMBL2386568)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434329(CHEMBL2386554)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19234(4-{[4-(3-{4-[(Benzyl{2-methyl-3-[(methylsulfonyl)a...)
Affinity DataIC50: 0.600nM EC50:  86nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195145((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(4-me...)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434318(CHEMBL2386566)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195158((8S,11S,13S,14S,17S)-11-(2,6-difluoro-4-methoxy-ph...)
Affinity DataIC50: 0.700nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195160((8S,11R,13S,14S,17S)-17-hydroxy-11-(4'-methoxy-bip...)
Affinity DataIC50: 0.700nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434317(CHEMBL2386567)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195153((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-phen...)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19234(4-{[4-(3-{4-[(Benzyl{2-methyl-3-[(methylsulfonyl)a...)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434315(CHEMBL2386569)
Affinity DataIC50: 1nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434313(CHEMBL2386571)
Affinity DataIC50: 1nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.10nM EC50:  4.80nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195157((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-3-me...)
Affinity DataIC50: 1.10nMAssay Description:Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434314(CHEMBL2386570)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434322(CHEMBL2386562)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195155(A-348441 | CHEMBL219684)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434314(CHEMBL2386570)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434315(CHEMBL2386569)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434316(CHEMBL2386568)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195148((8S,11R,13S,14S,17S)-11-(4-allyloxy-3-chloro-5-met...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195154((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(4-ph...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434320(CHEMBL2386564)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434317(CHEMBL2386567)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50434313(CHEMBL2386571)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19236(2-{2-bromo-5-[4-({[(2,4-difluorophenyl)methyl](3-m...)
Affinity DataIC50: 1.80nM EC50:  330nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195145((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(4-me...)
Affinity DataIC50: 1.80nMAssay Description:Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 1.90nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19237(2-[4-(4-{[benzyl(3-methanesulfonamido-2-methylphen...)
Affinity DataIC50: 2.10nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150333(N-[3-(Benzyl-{4-[4-((1R,3S)-4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150340((3R,5S)-6-[4-(4-{[Benzyl-(3-methanesulfonylamino-2...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150336((4R,6S)-4-Hydroxy-6-({[4-((8S,11R,13S,14S,17S)-17-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19233((2R,10S,11S,14S,15S)-14-hydroxy-15-methyl-2-[(4-me...)
Affinity DataIC50: 2.40nM EC50:  43nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19233((2R,10S,11S,14S,15S)-14-hydroxy-15-methyl-2-[(4-me...)
Affinity DataIC50: 2.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195149((4R)-4-[(1S,2S,5S,7R,9R,10R,11S,14R,15R,16S)-9,16-...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 2.60nM EC50:  500nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150321(N-{3-[Benzyl-(4-phenoxy-benzyl)-amino]-2-methyl-ph...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195143((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-3,5-...)
Affinity DataIC50: 2.80nMAssay Description:Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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