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TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116537(3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human whole blood LTB-4 production (Leukotriene B-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50125433(1-[2-(4-Benzyl-phenoxy)-ethyl]-1H-imidazo[4,5-b]py...)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50271083(5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116563(N-(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116554(N-(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116562([4-(4-Benzyl-phenoxy)-butylamino]-acetic acid | CH...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116560(3-{Methyl-[3-(4-thiophen-3-ylmethyl-phenoxy)-propy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116544(2-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-eth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116542(3-{Methyl-[3-(4-thiophen-2-ylmethyl-phenoxy)-propy...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085261([2-(4-Benzyl-phenoxy)-ethyl]-dimethyl-amine | CHEM...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085288(1-{2-[4-(Biphenyl-4-yloxy)-phenoxy]-ethyl}-pyrroli...)
Affinity DataIC50: 6.60nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085282(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-pyridine | C...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116561(3-[4-(4-Benzyl-phenoxy)-butylamino]-propionic acid...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116548(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50125435(1-[2-(4-Benzyl-phenoxy)-ethyl]-1H-imidazo[4,5-b]py...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085290(2-(4-benzylphenoxy)ethanamine | 2-(4-Benzyl-phenox...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50125420(5-[2-(4-Benzyl-phenoxy)-ethyl]-5H-imidazo[4,5-c]py...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085277(1-{2-[4-(Difluoro-phenyl-methyl)-phenoxy]-ethyl}-p...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116532([4-(4-Benzyl-phenoxy)-butylamino]-acetic acid ethy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50121000({2-[2-(4-Benzyl-phenoxy)-ethyl]-2-aza-bicyclo[2.2....)
Affinity DataIC50: 15nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50121000({2-[2-(4-Benzyl-phenoxy)-ethyl]-2-aza-bicyclo[2.2....)
Affinity DataIC50: 15nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50121003(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine-3-carbo...)
Affinity DataIC50: 16nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313205(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116529(3-{Methyl-[3-(4-thiophen-2-ylmethyl-phenoxy)-propy...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085270(2-[2-(4-Benzyl-phenoxy)-ethyl]-2,5-diaza-bicyclo[2...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116531(3-[4-(4-Benzyl-phenoxy)-butylamino]-propionic acid...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116533(3-{Methyl-[3-(4-phenoxy-phenoxy)-propyl]-amino}-pr...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50121009(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidin-3-ylamin...)
Affinity DataIC50: 20nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085297(1-[2-(4-Benzyl-phenoxy)-ethyl]-2,6-dimethyl-piperi...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336012(6-chloro-8-(4-chlorophenyl)-2-(trifluoromethyl)-2H...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085279(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine | 1-[2-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085279(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine | 1-[2-...)
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313223(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 26nMAssay Description:Inhibition of FLAPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085279(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine | 1-[2-...)
Affinity DataIC50: 26nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085252(Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy)-benzyl]-amine...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116535(3-(Methyl-{3-[4-(4-oxazol-2-yl-phenoxy)-phenoxy]-p...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50121023(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidin-3-ol | C...)
Affinity DataIC50: 30nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085248(1-[2-(4-Benzyloxy-phenoxy)-ethyl]-pyrrolidine | CH...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50125429(1-[2-(4-Benzyl-phenoxy)-ethyl]-1H-imidazo[4,5-c]py...)
Affinity DataIC50: 31nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116536(3-({3-[4-(4-Fluoro-benzyl)-phenoxy]-propyl}-methyl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085299(1-[2-(4-Thiophen-3-ylmethyl-phenoxy)-ethyl]-pyrrol...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50125421(3-[2-(4-Benzyl-phenoxy)-ethyl]-3H-imidazo[4,5-c]py...)
Affinity DataIC50: 36nMAssay Description:In vitro inhibition of recombinant human leukotriene A4 hydrolase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085262(1-[2-(5-Benzyl-thiophen-2-yloxy)-ethyl]-pyrrolidin...)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50085283(1-[2-(4-Benzyl-phenoxy)-ethyl]-azepane | CHEMBL159...)
Affinity DataIC50: 37nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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