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TargetHistone deacetylase 1(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor beta(Human)
University of Versailles Saint-Quentin-en-Yvelines

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50: 3nMAssay Description:Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50160371(7-Methoxy-6-oxazol-5-yl-3-(2-pyridin-4-yl-ethyl)-2...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392836(CHEMBL2151141)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50160379(7-Methoxy-3-methyl-6-oxazol-5-yl-2-thioxo-2,3-dihy...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50160378(3-(3-Imidazol-1-yl-propyl)-7-methoxy-6-oxazol-5-yl...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50160375(7-Methoxy-6-oxazol-5-yl-2-thioxo-2,3-dihydro-1H-qu...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50174783(1-tert-butyl 5-methyl (3S,5R)-7'-methoxy-3'-methyl...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392838(CHEMBL2151179)
Affinity DataIC50: 42nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50174782(N,N-diethyl-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50160374(3-[2-(1H-Imidazol-4-yl)-ethyl]-7-methoxy-6-oxazol-...)
Affinity DataIC50: 47nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Celltech R and D

Curated by ChEMBL
LigandPNGBDBM50174790(7-methoxy-2,3-dimethyl-6-(oxazol-5-yl)-2-styryl-2,...)
Affinity DataIC50: 49nMAssay Description:Inhibitory activity against IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM586102(US11530244, Compound 004)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586103(US11530244, Compound 005)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586105(US11530244, Compound 007)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586108(US11530244, Compound 010)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586117(US11530244, Compound 034)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586118(US11530244, Compound 035)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586119(US11530244, Compound 036)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586121(US11530244, Compound 038)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586128(US11530244, Compound 046)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586133(US11530244, Compound 051)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586136(US11530244, Compound 054)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586140(US11530244, Compound 058)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586147(US11530244, Compound 065)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586148(US11530244, Compound 066)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586149(US11530244, Compound 067)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586150(US11530244, Compound 068)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586157(US11530244, Compound 130)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586164(US11530244, Compound 146)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586169(US11530244, Compound 152)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586175(US11530244, Compound 171)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586179(US11530244, Compound 184)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586180(US11530244, Compound 185)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586200(US11530244, Compound 223)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50554744(CHEMBL4759663 | US11530244, Compound 248)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586214(US11530244, Compound 275)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586215(US11530244, Compound 276)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586216(US11530244, Compound 277)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586217(US11530244, Compound 281)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586223(US11530244, Compound 293)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM586225(US11530244, Compound 296)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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