Report error Found 55 with Last Name = 'golshayan' and Initial = 'd'
TargetProprotein convertase subtilisin/kexin type 7(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC7 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 5(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC6 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetNeuroendocrine convertase 2(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataKi: 0.360nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC2 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC1 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetNeuroendocrine convertase 1(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC3 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC4 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Binding affinity to AT1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch activationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in HEK293 cells after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signalingMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of gamma secretase in human SupT1 cells assessed as reduction in amyloid beta 40 after 16 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in human SupT1 cells after 16 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human gamma secretase expressing APP751 by electrochemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma secretase in human MCF7 cells assessed as reduction in amyloid beta 40 after 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of ADAM10 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase isolated from human HeLa cell derived P2 membrane assessed as reduction in amyloid beta (1 to 40 residues) using recomb...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Universitaire Vaudois
Curated by ChEMBL
Universitaire Vaudois
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of tankyrase1/2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signalingMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated APP cleavage in CHO cells expressing APP Swedish KM/NL mutant assessed as reduction in amyloi...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human S1P2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat S1P2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP assessed as reduction in amyloid beta levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of full-length human gamma secretase expressed in SH-SY5Y spbetaA4CTF cells assessed as reduction in amyloid beta levels after 90 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of gamma secretase in human primary neuronal cells assessed as reduction in amyloid beta 40More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Modulation of gamma secretase in HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta levels after 5 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 209nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch M1726V mutant activation in CHO K1 cells after 48 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signaling by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataIC50: 541nMAssay Description:Inhibition of ADAM17 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of gamma secretase mediated Notch delta E activation in human HeLa cells expressing EGFP after 16 hrs by immunofluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CBP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (Chuv)
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma secretase mediated amyloid beta level reduction in HEK293 cells expressing APP after 72 hrs by chemiluminescence assayMore data for this Ligand-Target Pair