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TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataIC50:  0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50:  0.0100nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM258470(US9522888, 697)
Affinity DataIC50:  0.0140nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312996((R,S)-3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(3-(2,...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313013(CHEMBL1080901 | CT-98024 | N2-(2-(4-(2,4-dichlorop...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50451624(CHEMBL331897)
Affinity DataIC50:  0.580nMAssay Description:Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50451624(CHEMBL331897)
Affinity DataIC50:  0.900nMAssay Description:Binding affinity towards C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312997(3-(3-(3-hydroxypropylamino)phenyl)-4-(1-methyl-1H-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM2647((Phenylindolyl)maleimide deriv. 69 | 3-(3-aminophe...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312998((R,S)-3-(3-(2,3-dihydroxypropyl)phenyl)-4-(5-fluor...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102578(US8536172, I-27)
Affinity DataIC50:  2nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50099482(2-(6-Amino-benzothiazol-2-ylsulfanyl)-N-[1-(3,4-di...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102593(US8536172, I-42)
Affinity DataIC50:  2.40nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50133793(1-{(S)-1-[3-(4-Chloro-benzyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  2.40nMAssay Description:Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313010(3-(2,4-dimethoxyphenyl)-4-(1-methyl-1H-indol-3-yl)...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50:  3nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50:  3nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102565(US8536172, I-14)
Affinity DataIC50:  3nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50:  3nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50:  3.10nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313000((R)-3-(3-(2,3-dihydroxypropyl)phenyl)-4-(1-methyl-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102602(US8536172, I-51)
Affinity DataIC50:  3.60nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102566(US8536172, I-15)
Affinity DataIC50:  3.60nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102573(US8536172, I-22)
Affinity DataIC50:  3.60nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM2651((Phenylindolyl)maleimide deriv. 73 | 3-(2-chloroph...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102577(US8536172, I-26)
Affinity DataIC50:  3.70nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102576(US8536172, I-25)
Affinity DataIC50:  4.20nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50133792(1-{(S)-1-[3-(4-Chloro-benzyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  4.40nMAssay Description:Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102606(US8536172, I-55)
Affinity DataIC50:  4.40nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50133796(1-{(R)-2-[3-(4-Chloro-benzyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  4.70nMAssay Description:Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102589(US8536172, I-38)
Affinity DataIC50:  4.90nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  5nMAssay Description:Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50:  5.40nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  5.80nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102570(US8536172, I-19)
Affinity DataIC50:  6.10nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102602(US8536172, I-51)
Affinity DataIC50:  6.20nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50492029(CHEMBL2390974)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313003(3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(3-methoxyph...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313009(3-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-indol-3-yl)...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50:  6.60nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50:  6.80nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50492032(CHEMBL2392831)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313011(31-(dimethylamino)-5,11,15,25,30-pentaazaheptacycl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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