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TargetBromodomain and PHD finger-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  126nMAssay Description:Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50189403(CHEMBL3828191)
Affinity DataKd:  0.316nMAssay Description:Inhibition of human BRPF1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRD9 isoform 1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  4nMAssay Description:Binding affinity to full length BRD2 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  4nMAssay Description:Binding affinity to full length BRD3 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged SMARCA4 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  63nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to BRD4 BD2 (333 to 460 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  1.58E+4nMAssay Description:Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  2.51E+4nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  10nMAssay Description:Binding affinity to full length BRDT BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413563(CHEMBL469376)
Affinity DataEC50:  25.1nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50526964(CHEMBL4438171)
Affinity DataKd:  5nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  1.58E+4nMAssay Description:Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417427(CHEMBL1290716)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD5 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417410(CHEMBL1290596)
Affinity DataEC50:  5.01nMAssay Description:Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50603097(CHEMBL5195288)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to BRD3 BD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  19nMAssay Description:Binding affinity to human partial length DNA-tagged BRD3 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514899(CHEMBL4461619)
Affinity DataKd:  10nMAssay Description:Binding affinity to CECR2 (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50540499(CHEMBL4635496)
Affinity DataKd:  2nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365264(CHEMBL1738926)
Affinity DataKd:  19nMAssay Description:Binding affinity to His6-tagged BRD3 expressed in Escherichia coli by isothermal colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd: <2.51E+4nMAssay Description:Binding affinity to full length BRD2 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417421(CHEMBL1290597)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TRIM24(PHD,Bromo.) expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd: <2.00E+4nMAssay Description:Binding affinity to full length BRD4 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged EP300 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PCAF expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  20nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417427(CHEMBL1290716)
Affinity DataEC50:  0.0316nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50147620(CHEMBL3769507)
Affinity DataKd:  398nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to N-terminal His-tagged BRD4 BD1 (unknown origin) by isothermal calorimetric titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1-like(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  25nMAssay Description:Binding affinity to human partial length TAF1L bromodomain 2 (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  25nMAssay Description:Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain and PHD finger-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRPF3 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD3 BD1 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50147620(CHEMBL3769507)
Affinity DataKd:  2nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  32nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.45E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TAF1 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365264(CHEMBL1738926)
Affinity DataKd:  52nMAssay Description:Binding affinity to His6-tagged BRD2 expressed in Escherichia coli by isothermal colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50183448(CHEMBL3823478 | US11773085, Compound B2)
Affinity DataKd:  0.794nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to human TRIM24 bromodomain by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase TRIM33(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TRIM33(PHD,Bromo.) expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  16nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 1 (P24 to E144 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
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