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TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157710(CHEMBL3787204)
Affinity DataEC50: >4.70E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157651(CHEMBL3787566)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157652(CHEMBL3785110)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157631(CHEMBL3785736)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157702(CHEMBL3786639 | US11136336, Med. Chem. 2016, 59, 2...)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157707(CHEMBL3787359)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157709(CHEMBL3786508)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157710(CHEMBL3787204)
Affinity DataEC50: >4.70E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157651(CHEMBL3787566)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157652(CHEMBL3785110)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157631(CHEMBL3785736)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157702(CHEMBL3786639 | US11136336, Med. Chem. 2016, 59, 2...)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157707(CHEMBL3787359)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157709(CHEMBL3786508)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50375681(CHEMBL411630)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376025(AMG-0309 | CHEMBL409538)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376040(CHEMBL272824)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376042(CHEMBL409512)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376019(CHEMBL429585)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376026(CHEMBL272691)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376030(CHEMBL269916)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376036(CHEMBL270092)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50375996(CHEMBL272250)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50375999(CHEMBL270342)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50375679(CHEMBL270548)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50375690(CHEMBL270954)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376033(CHEMBL270985)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376034(CHEMBL271563)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376035(AMG-6168 | CHEMBL411091)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50375683(CHEMBL409867)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50376024(CHEMBL259461)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376038(CHEMBL412291)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376032(CHEMBL407715)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50376023(CHEMBL408478)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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