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TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288457(CHEMBL317974 | macrocyclic tripeptide motif)
Affinity DataKi:  1nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288454(CHEMBL317527 | N-[3-((5S,20R,22aR)-5-Benzyl-4,7,18...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288451(CHEMBL319017 | N-{3-[(5S,15S,19R,21aR)-5-Benzyl-15...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288453(CHEMBL317353 | N-[3-((5S,15S,19R,21aR)-5-Benzyl-4,...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288457(CHEMBL317974 | macrocyclic tripeptide motif)
Affinity DataKi:  4.10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288453(CHEMBL317353 | N-[3-((5S,15S,19R,21aR)-5-Benzyl-4,...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288451(CHEMBL319017 | N-{3-[(5S,15S,19R,21aR)-5-Benzyl-15...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288454(CHEMBL317527 | N-[3-((5S,20R,22aR)-5-Benzyl-4,7,18...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288460(CHEMBL101049 | N-[3-((5S,18R,20aR)-5-Benzyl-4,7,16...)
Affinity DataKi:  10nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208222((E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobe...)
Affinity DataKi:  11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288458(CHEMBL431429 | N-[3-((5S,18R,20aR)-4,7,16,17,20-Pe...)
Affinity DataKi:  11nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288459(CHEMBL317428 | N-[3-((5S,18R,20aR)-5-Benzyl-2-meth...)
Affinity DataKi:  13nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288452(CHEMBL99281 | N-[3-((5S,18R,20aR)-4,7,16,17,20-Pen...)
Affinity DataKi:  14nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288455(CHEMBL100712 | N-[3-((5S,21R,23aR)-5-Benzyl-4,7,19...)
Affinity DataKi:  15nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288452(CHEMBL99281 | N-[3-((5S,18R,20aR)-4,7,16,17,20-Pen...)
Affinity DataKi:  20nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288460(CHEMBL101049 | N-[3-((5S,18R,20aR)-5-Benzyl-4,7,16...)
Affinity DataKi:  24nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288455(CHEMBL100712 | N-[3-((5S,21R,23aR)-5-Benzyl-4,7,19...)
Affinity DataKi:  25nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208228(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataKi:  36nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetCathepsin G(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  38nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288450(CHEMBL328200 | N-[3-((6S,19R,21aR)-6-Benzyl-5,8,17...)
Affinity DataKi:  66nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288450(CHEMBL328200 | N-[3-((6S,19R,21aR)-6-Benzyl-5,8,17...)
Affinity DataKi:  86nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288459(CHEMBL317428 | N-[3-((5S,18R,20aR)-5-Benzyl-2-meth...)
Affinity DataKi:  159nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288458(CHEMBL431429 | N-[3-((5S,18R,20aR)-4,7,16,17,20-Pe...)
Affinity DataKi:  163nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288456(CHEMBL430844 | N-[3-((5S,17R,19aR)-5-Benzyl-4,7,15...)
Affinity DataKi:  280nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288461(CHEMBL98856 | N-[3-((5S,16R,18aR)-5-Benzyl-4,7,14,...)
Affinity DataKi:  473nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50288461(CHEMBL98856 | N-[3-((5S,16R,18aR)-5-Benzyl-4,7,14,...)
Affinity DataKi:  710nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288456(CHEMBL430844 | N-[3-((5S,17R,19aR)-5-Benzyl-4,7,15...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin G(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208228(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Beta Pharma

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.800nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetVasopressin V2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50125101(Biphenyl-2-carboxylic acid [4-(1,3,4,5-tetrahydro-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity towards V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208271(US9266835, 44)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208271(US9266835, 44)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-rimonabant from human CB1 receptor expressed in CHO cell membranes after 60 mins by TopCount methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Beta Pharma

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.10nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208225((E)-2-(3-chlorostyrylamino)-1-(5-chlorobenzo[b]thi...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Beta Pharma

US Patent
LigandPNGBDBM643160(N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-met...)
Affinity DataIC50:  4.30nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208270(US9266835, 41)
Affinity DataIC50:  4.40nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [3H]-rimonabant from human CB1 receptor expressed in CHO cell membranes after 60 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-AVP from human V2 receptors expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataIC50:  6.90nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetFibroblast growth factor receptor 1(Human)
Beta Pharma

US Patent
LigandPNGBDBM643160(N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-met...)
Affinity DataIC50:  7.30nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 3(Human)
Beta Pharma

US Patent
LigandPNGBDBM643160(N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-met...)
Affinity DataIC50:  7.60nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50125112(Biphenyl-2-carboxylic acid [4-(2-oxo-1,2,2a,3,4,5-...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-AVP from human V2 receptors expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Beta Pharma

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  8.90nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Beta Pharma

US Patent
LigandPNGBDBM643160(N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-met...)
Affinity DataIC50:  9.5nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208236(1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50125103(4'-Methyl-biphenyl-2-carboxylic acid [4-(1,3,4,5-t...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-AVP from human V2 receptors expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208243((E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Beta Pharma

US Patent
LigandPNGBDBM643160(N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-met...)
Affinity DataIC50:  11nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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