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TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50095105(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0100nMAssay Description:Antagonistic activity of the compound against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364330(CHEMBL1949936)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364327(CHEMBL1949939)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202775(8-(furan-2-yl)-3-(2-(4-(4-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103771((4-{2-[4-(4-Methoxy-benzenesulfonyl)-phenyl]-[1,3]...)
Affinity DataKi:  0.140nMAssay Description:Antagonistic activity of the compound against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103774((5-Fluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-ben...)
Affinity DataKi:  0.200nMAssay Description:Antagonistic activity of the compound against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364339(CHEMBL1950085)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50345941(9-(2-Methyl-allylamino)-3-p-tolyl-3H-pyrido[3',2':...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306440(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306442((6aS,13bS)-11-chloro-7-methyl-4-phenyl-6,6a,7,8,9,...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306314((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103772((5,7-Difluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy...)
Affinity DataKi:  0.230nMAssay Description:Antagonistic activity of the compound against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103767((5,8-Difluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy...)
Affinity DataKi:  0.290nMAssay Description:Antagonistic activity of the compound against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202777(3-(2-(4-(4-chloro-2-fluorophenyl)piperazin-1-yl)et...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50258880(8-(dio-tolylmethyl)-3-phenyl-8-azabicyclo[3.2.1]oc...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human cloned NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364340(CHEMBL1950084)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50124943((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50256362(CHEMBL470942 | N7-(cyclopropylmethyl)-N7-(2-(4-(2,...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SCH58261 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50256419(CHEMBL480542 | N7-(2-(4-(2,4-difluorophenyl)pipera...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SCH58261 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50256492(CHEMBL480570 | N7-(2-(4-(2,4-difluorophenyl)pipera...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SCH58261 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306452((6aS,13bS)-11-chloro-7-methyl-4-(pyridin-4-yl)-6,6...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210235(4-(2-(aminomethyl)phenyl)-1-(1-phenylpentyl)piperi...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202771(8-(furan-2-yl)-3-(2-(4-(4-(2-methoxyethoxy)-2-(tri...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202788(3-(2-(4-(3-chlorophenyl)piperazin-1-yl)ethyl)-8-(f...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202991(7-(2-{4-[2-fluoro-4-(2-methoxy-ethoxy)-phenyl]-pip...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50373621(CHEMBL403414)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50124953((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50364723(CHEMBL1951662)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50345942(3-(4-Methoxy-phenyl)-9-(2-methyl-allylamino)-3H-py...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306443((6aS,13bS)-11-chloro-4-(3-fluorophenyl)-7-methyl-6...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364335(CHEMBL1950089)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210247(4-(2-(aminomethyl)phenyl)-1-(1-phenylhexyl)piperid...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210229(4-(2-(aminomethyl)phenyl)-1-((2-chlorophenyl)(phen...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210212(4-(2-(aminomethyl)phenyl)-1-(bis(2-chlorophenyl)me...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210206(4-(2-(aminomethyl)phenyl)-1-(dio-tolylmethyl)piper...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202994(7-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-2...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362726(CHEMBL1939796)
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50210242(4-(2-(aminomethyl)phenyl)-1-(bis(2-fluorophenyl)me...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306316((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306322(CHEMBL597909 | N-((6aS,13bR)-11-chloro-12-hydroxy-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50256300(CHEMBL514939 | N7-(2-(4-(2,4-difluorophenyl)pipera...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]SCH58261 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50252010(2-Furan-2-yl-7-[2-(4'-methoxy-biphenyl-4-yl)-ethyl...)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306315((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103773((4-Fluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-ben...)
Affinity DataKi:  0.510nMAssay Description:Binding affinity for human Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103768((5-Bromo-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-benz...)
Affinity DataKi:  0.510nMAssay Description:Antagonistic activity of the compound against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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