Compile Data Set for Download or QSAR
Report error Found 316 with Last Name = 'griswold' and Initial = 'de'
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105748({4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidaz...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105762(4-[4-(4-Fluoro-phenyl)-5-(2-phenylamino-pyrimidin-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105746({4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472190(CHEMBL167638)
Affinity DataIC50: 5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrroli...)
Affinity DataIC50: 5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2-beta-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140791(1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...)
Affinity DataIC50: 6nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105743(4-[3-(1-Benzyl-piperidin-4-yl)-5-(4-fluoro-phenyl)...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105763(Ethyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperidi...)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 10nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001611((Z)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Affinity DataIC50: 12nMAssay Description:Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001611((Z)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105751(4-[4-(4-Fluoro-phenyl)-5-(2-phenoxy-pyrimidin-4-yl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PKC-beta2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105761(4-[4-(4-Fluoro-phenyl)-5-(2-methylamino-pyrimidin-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of JNK 2 beta-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099374(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140795(1-(2-Bromo-phenyl)-3-(3-chloro-4-cyano-2-hydroxy-p...)
Affinity DataIC50: 22nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140796(1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...)
Affinity DataIC50: 25nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105760({4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidaz...)
Affinity DataIC50: 27nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472191(CHEMBL167166)
Affinity DataIC50: 40nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105759(4-{5-(4-Fluoro-phenyl)-3-[1-(2,2,2-trifluoro-ethyl...)
Affinity DataIC50: 42nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472193(CHEMBL352628)
Affinity DataIC50: 44nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472187(CHEMBL169746)
Affinity DataIC50: 45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105754(Benzyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperid...)
Affinity DataIC50: 45nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50104352(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50403384(CHEMBL17445)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM13531(4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50403407(CHEMBL17210)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50230001(4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472198(CHEMBL354447)
Affinity DataIC50: 52nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105744(2-{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105755(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50: 53nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140789(1-(2-Bromo-phenyl)-3-(4-chloro-3-cyano-2-hydroxy-p...)
Affinity DataIC50: 57nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105741(4-[5-(4-Fluoro-phenyl)-3-(2,2,6,6-tetramethyl-pipe...)
Affinity DataIC50: 58nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 316 total ) | Next | Last >>
Jump to: