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TargetSodium- and chloride-dependent betaine transporter(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to BGT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataKi:  6.10E+3nMAssay Description:Binding affinity to GAT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataKi:  2.70E+4nMAssay Description:Binding affinity to GAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50089759((R)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  50nMAssay Description:Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50079387(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Affinity DataIC50:  83nMAssay Description:Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  200nMAssay Description:Binding affinity to GAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50020882(1-(4,4-Diphenyl-but-3-enyl)-1,2,5,6-tetrahydro-pyr...)
Affinity DataIC50:  200nMAssay Description:Binding affinity to GAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50089759((R)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  213nMAssay Description:Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50079387(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Affinity DataIC50:  277nMAssay Description:Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50437144(CHEMBL1190271)
Affinity DataIC50:  309nMAssay Description:Inhibition of GABA uptake at GAT-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165461((S)-1-(4-Chloro-phenyl)-2-((S)-6,7-dimethoxy-2-met...)
Affinity DataIC50:  400nMAssay Description:Mean inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50089760((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  545nMAssay Description:Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50437145(CHEMBL1196076)
Affinity DataIC50:  646nMAssay Description:Inhibition of GABA uptake at GAT-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165458((S)-2-((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataIC50:  790nMAssay Description:Mean inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165461((S)-1-(4-Chloro-phenyl)-2-((S)-6,7-dimethoxy-2-met...)
Affinity DataIC50:  1.32E+3nMAssay Description:Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2B expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165458((S)-2-((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataIC50:  3.16E+3nMAssay Description:Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2B expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50343258(4-((4,4-bis(3-methylthiophen-2-yl)but-3-enyl)(meth...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity to GAT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  5.01E+3nMAssay Description:Inhibition of human GAT3 assessed as [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50089760((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  5.10E+3nMAssay Description:Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50089760((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  5.10E+3nMAssay Description:Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165461((S)-1-(4-Chloro-phenyl)-2-((S)-6,7-dimethoxy-2-met...)
Affinity DataIC50:  5.29E+3nMAssay Description:Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2C expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  7.24E+3nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419348(CHEMBL1917037)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50247181(2,6-Difluoro-3-({2-[tris-(4-methoxyphenyl)methoxy]...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419350(CHEMBL1917042)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
Ludwig-Maximilians-UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50165457((S)-1-(4-Chloro-phenyl)-2-((S)-6,7-dimethoxy-1,2,3...)
Affinity DataIC50:  1.05E+4nMAssay Description:Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2B expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-methyl-D-aspartate receptor(Pig)
Zentrum FüR Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM50079387(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Affinity DataIC50:  1.13E+4nMAssay Description:Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419353(CHEMBL1917045)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419352(CHEMBL1917039)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419340(CHEMBL1917041)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419345(CHEMBL1917033)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419352(CHEMBL1917039)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50026410(CHEBI:16974 | Imidazole acetic acid)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419339(CHEMBL1917040)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419341(CHEMBL1917043)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of rat GAT2 assessed as [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419351(CHEMBL1917046)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50000102(3-aminopropanoic acidbeta-alanine | Alanine-beta |...)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419339(CHEMBL1917040)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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