Compile Data Set for Download or QSAR
Found 955 with Last Name = 'hamon' and Initial = 'm'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Show SMILES COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1
Show InChI InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Show SMILES [O-][N+](=O)c1ccc2nc(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2
Affinity DataKi:  0.120nMAssay Description:Ability to displace [3H]paroxetine bound to Serotonin transporter receptor in rat forebrainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Show SMILES [O-][N+](=O)c1ccc2nc(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2
Affinity DataKi:  0.120nMAssay Description:Binding affinity towards Serotonin transporter was determined in rat forebrain membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM82368(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM81789(5-CT,DP | CAS_156314 | DP-5-CT | NN-DIPROP-5-CT | ...)
Show SMILES CCCN(CCC)CCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM21392(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)
Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063263(6-(4-Methyl-piperazin-1-yl)-7,8,9,10-tetrahydro-ph...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2CCCCc12
Show InChI InChI=1S/C18H23N3/c1-20-10-12-21(13-11-20)18-16-8-3-2-6-14(16)15-7-4-5-9-17(15)19-18/h4-5,7,9H,2-3,6,8,10-13H2,1H3
Affinity DataKi:  0.230nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063263(6-(4-Methyl-piperazin-1-yl)-7,8,9,10-tetrahydro-ph...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2CCCCc12
Show InChI InChI=1S/C18H23N3/c1-20-10-12-21(13-11-20)18-16-8-3-2-6-14(16)15-7-4-5-9-17(15)19-18/h4-5,7,9H,2-3,6,8,10-13H2,1H3
Affinity DataKi:  0.230nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM50035508(4-Iodo-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Show SMILES COc1ccccc1N1CCN(CCN(C(=O)c2ccc(I)cc2)c2ccccn2)CC1
Show InChI InChI=1S/C25H27IN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50449636(BRL-43694 | GRANISETRON | Kytril | LY-278584 | San...)
Show SMILES CN1[C@H]2CCC[C@@H]1C[C@H](C2)NC(=O)c1nn(C)c2ccccc12
Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13-,14+
Affinity DataKi:  0.350nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM50033112(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyla...)
Show SMILES COc1ccccc1N1CCN(CCCNc2c(C)c(=O)n(C)c(=O)n2C)CC1
Show InChI InChI=1S/C21H31N5O3/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4/h5-6,8-9,22H,7,10-15H2,1-4H3
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076415(2-[2-(4-Methyl-piperazin-1-yl)-4-phenyl-quinolin-3...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(-c2ccccc2)c1CCO
Show InChI InChI=1S/C22H25N3O/c1-24-12-14-25(15-13-24)22-19(11-16-26)21(17-7-3-2-4-8-17)18-9-5-6-10-20(18)23-22/h2-10,26H,11-16H2,1H3
Affinity DataKi:  0.400nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50060685(9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-8-10-20(11-9-19)16-14-6-3-7-21(14)15-12(17)4-2-5-13(15)18-16/h2-7H,8-11H2,1H3
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Show SMILES Cc1cccc2nc(N3CCN(Cc4cnc[nH]4)CC3)c3cccn3c12
Show InChI InChI=1S/C20H22N6/c1-15-4-2-5-17-19(15)26-7-3-6-18(26)20(23-17)25-10-8-24(9-11-25)13-16-12-21-14-22-16/h2-7,12,14H,8-11,13H2,1H3,(H,21,22)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076416(2-[4-(2-Fluoro-phenyl)-2-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(c1CCO)-c1ccccc1F
Show InChI InChI=1S/C22H24FN3O/c1-25-11-13-26(14-12-25)22-18(10-15-27)21(16-6-2-4-8-19(16)23)17-7-3-5-9-20(17)24-22/h2-9,27H,10-15H2,1H3
Affinity DataKi:  0.600nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076401(CHEMBL41511 | [2-(4-Methyl-piperazin-1-yl)-4-pheny...)
Show SMILES CCOC(=O)Cc1c(nc2ccccc2c1-c1ccccc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H27N3O2/c1-3-29-22(28)17-20-23(18-9-5-4-6-10-18)19-11-7-8-12-21(19)25-24(20)27-15-13-26(2)14-16-27/h4-12H,3,13-17H2,1-2H3
Affinity DataKi:  0.600nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3cnc[nH]3)CC1)c1cccn21
Show InChI InChI=1S/C19H19FN6/c20-14-3-4-17-16(10-14)23-19(18-2-1-5-26(17)18)25-8-6-24(7-9-25)12-15-11-21-13-22-15/h1-5,10-11,13H,6-9,12H2,(H,21,22)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076408(4-(2-Fluoro-phenyl)-2-(4-methyl-piperazin-1-yl)-3-...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(c1CCOC1CCCO1)-c1ccccc1F
Show InChI InChI=1S/C26H30FN3O2/c1-29-13-15-30(16-14-29)26-21(12-18-32-24-11-6-17-31-24)25(19-7-2-4-9-22(19)27)20-8-3-5-10-23(20)28-26/h2-5,7-10,24H,6,11-18H2,1H3
Affinity DataKi:  0.700nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM82367(CAS_141533-35-9 | SDZ 216,525 | SDZ 216-525)
Show SMILES COC(=O)c1cc2c(cccc2[nH]1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C25H28N4O5S/c1-34-25(31)21-17-19-20(26-21)8-6-9-22(19)28-15-13-27(14-16-28)11-4-5-12-29-24(30)18-7-2-3-10-23(18)35(29,32)33/h2-3,6-10,17,26H,4-5,11-16H2,1H3
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50081973(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2cc(O)ccc2n2cccc12
Show InChI InChI=1S/C16H18N4O/c1-18-7-9-19(10-8-18)16-15-3-2-6-20(15)14-5-4-12(21)11-13(14)17-16/h2-6,11,21H,7-10H2,1H3
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]zacopride from 5HT3 receptor in rat cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50451023(MESULERGINE)
Show SMILES CN(C)S(=O)(=O)NC[C@H]1C[C@H]2[C@@H](Cc3cn(C)c4cccc2c34)N(C)C1
Show InChI InChI=1S/C19H28N4O2S/c1-21(2)26(24,25)20-10-13-8-16-15-6-5-7-17-19(15)14(12-23(17)4)9-18(16)22(3)11-13/h5-7,12-13,16,18,20H,8-11H2,1-4H3/t13-,16-,18-/m1/s1
Affinity DataKi:  0.730nMAssay Description:Ability to displace [3H]mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50081969(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50258431(CHEMBL523716 | [4-(7-Fluoropyrrolo[1,2-a]quinoxali...)
Show SMILES ONC(=N)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H19FN6O/c18-12-3-4-14-13(10-12)20-17(15-2-1-5-24(14)15)23-8-6-22(7-9-23)11-16(19)21-25/h1-5,10,25H,6-9,11H2,(H2,19,21)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50081969(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]zacopride from 5HT3 receptor in rat cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076427(2-(4-Methyl-piperazin-1-yl)-4-phenyl-3-[2-(tetrahy...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(c1CCOC1CCCO1)-c1ccccc1
Show InChI InChI=1S/C26H31N3O2/c1-28-14-16-29(17-15-28)26-22(13-19-31-24-12-7-18-30-24)25(20-8-3-2-4-9-20)21-10-5-6-11-23(21)27-26/h2-6,8-11,24H,7,12-19H2,1H3
Affinity DataKi:  0.800nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063260(10-(4-methylhexahydro-1-pyrazinyl)-9-azatetracyclo...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2C3CCC(C3)Cc12
Show InChI InChI=1S/C20H25N3/c1-22-8-10-23(11-9-22)20-17-13-14-6-7-15(12-14)19(17)16-4-2-3-5-18(16)21-20/h2-5,14-15H,6-13H2,1H3
Affinity DataKi:  0.830nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076410(2-[2-(4-Methyl-piperazin-1-yl)-3-vinyl-quinolin-4-...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(c1C=C)-c1ccccc1O
Show InChI InChI=1S/C22H23N3O/c1-3-16-21(18-9-5-7-11-20(18)26)17-8-4-6-10-19(17)23-22(16)25-14-12-24(2)13-15-25/h3-11,26H,1,12-15H2,2H3
Affinity DataKi:  0.900nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076421(CHEMBL42912 | [2-(4-Methyl-piperazin-1-yl)-4-pheny...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(-c2ccccc2)c1CO
Show InChI InChI=1S/C21H23N3O/c1-23-11-13-24(14-12-23)21-18(15-25)20(16-7-3-2-4-8-16)17-9-5-6-10-19(17)22-21/h2-10,25H,11-15H2,1H3
Affinity DataKi:  0.980nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP Ki Database
LigandPNGBDBM82366(5-OME-3-ADTN)
Show SMILES COc1c(O)c(O)cc2CCC(N)Cc12
Show InChI InChI=1S/C11H15NO3/c1-15-11-8-5-7(12)3-2-6(8)4-9(13)10(11)14/h4,7,13-14H,2-3,5,12H2,1H3
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataKi:  1.10nMAssay Description:Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataKi:  1.10nMAssay Description:Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatumMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
Affinity DataKi:  1.20nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
Affinity DataKi:  1.20nMAssay Description:Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL
LigandPNGBDBM50258495((R)-2-Amino-3-[4-(7-fluoropyrrolo[1,2-a]quinoxalin...)
Show SMILES N[C@H](CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12)C(O)=O
Show InChI InChI=1S/C18H20FN5O2/c19-12-3-4-15-14(10-12)21-17(16-2-1-5-24(15)16)23-8-6-22(7-9-23)11-13(20)18(25)26/h1-5,10,13H,6-9,11,20H2,(H,25,26)/t13-/m1/s1
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
Affinity DataKi:  1.20nMAssay Description:Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50011247(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
Affinity DataKi:  1.20nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50031942((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Show SMILES CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34
Show InChI InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1
Affinity DataKi:  1.60nMAssay Description:Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50031932(7-(4-Methyl-piperazin-1-yl)-6H-5-oxa-8-aza-benzo[c...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1COc1ccccc-21
Show InChI InChI=1S/C21H21N3O/c1-23-10-12-24(13-11-23)21-17-14-25-19-9-5-3-7-16(19)20(17)15-6-2-4-8-18(15)22-21/h2-9H,10-14H2,1H3
Affinity DataKi:  1.60nMAssay Description:Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50063264(6-Piperazin-1-yl-7,8,9,10-tetrahydro-phenanthridin...)
Show SMILES C1CCc2c(C1)c(nc1ccccc21)N1CCNCC1
Show InChI InChI=1S/C17H21N3/c1-2-7-15-13(5-1)14-6-3-4-8-16(14)19-17(15)20-11-9-18-10-12-20/h3-4,6,8,18H,1-2,5,7,9-12H2
Affinity DataKi:  1.70nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076396(2-(4-Methyl-piperazin-1-yl)-indeno[1,2,3-de]quinol...)
Show SMILES CN1CCN(CC1)c1cc2-c3ccccc3-c3cccc(n1)c23
Show InChI InChI=1S/C20H19N3/c1-22-9-11-23(12-10-22)19-13-17-15-6-3-2-5-14(15)16-7-4-8-18(21-19)20(16)17/h2-8,13H,9-12H2,1H3
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
Affinity DataKi:  1.80nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universit£ di Siena

Curated by ChEMBL
LigandPNGBDBM50076422(4-(2-Fluoro-phenyl)-2-(4-methyl-piperazin-1-yl)-3-...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c(c1CCOC1CCCCO1)-c1ccccc1F
Show InChI InChI=1S/C27H32FN3O2/c1-30-14-16-31(17-15-30)27-22(13-19-33-25-12-6-7-18-32-25)26(20-8-2-4-10-23(20)28)21-9-3-5-11-24(21)29-27/h2-5,8-11,25H,6-7,12-19H2,1H3
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissueMore data for this Ligand-Target Pair
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