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TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36588(AGM-1470)
Affinity DataEC50:  0.0370nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36589(Ovalicin)
Affinity DataEC50:  0.0180nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36590(FOS-72)
Affinity DataEC50:  0.0130nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36595(FOS-68)
Affinity DataEC50:  0.460nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36597(FOS-69)
Affinity DataEC50:  0.310nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36592(FOS-70)
Affinity DataEC50:  0.120nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36591(FOS-37)
Affinity DataEC50:  9.5nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36596(FOS-34)
Affinity DataEC50:  2.20nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36593(FOS-64)
Affinity DataEC50:  110nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36598(FOS-67)
Affinity DataEC50:  40nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36599(FOS-201)
Affinity DataEC50:  56nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36594(FOS-202)
Affinity DataEC50:  2.80E+3nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPyruvate dehydrogenase complex component E2(Human)
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50377913(HYPERFORIN)
Affinity DataKd:  578nMAssay Description:Binding affinity to recombinant GFP fused Dalt (unknown origin) by Lip-SMap analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human TrkB receptor ECD assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCell division protein FtsZ(Staphylococcus aureus)
Guangdong University of Technology

Curated by ChEMBL
LigandPNGBDBM50605149(CHEMBL5200927)
Affinity DataKd:  2.49E+3nMAssay Description:Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCell division protein FtsZ(Staphylococcus aureus)
Guangdong University of Technology

Curated by ChEMBL
LigandPNGBDBM50605150(CHEMBL5174791)
Affinity DataKd:  3.84E+3nMAssay Description:Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCell division protein FtsZ(Staphylococcus aureus)
Guangdong University of Technology

Curated by ChEMBL
LigandPNGBDBM50605151(CHEMBL5188114)
Affinity DataKd:  2.38E+3nMAssay Description:Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCell division protein FtsZ(Staphylococcus aureus)
Guangdong University of Technology

Curated by ChEMBL
LigandPNGBDBM50605152(CHEMBL5186593)
Affinity DataKd:  3.86E+3nMAssay Description:Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50198325(CHEMBL3941014)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36597(FOS-69)
Affinity DataIC50: 0.100nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36589(Ovalicin)
Affinity DataIC50: 0.400nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36588(AGM-1470)
Affinity DataIC50: 1nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [166-489](Human)
Novartis Institutes

LigandPNGBDBM203827(WNK463 (2) | WNK463 | N-(tert-butyl)-1-(1-(5-(5-(t...)
Affinity DataIC50: 1nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320036(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(3-nitrobenzo...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36595(FOS-68)
Affinity DataIC50: 2nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320040(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(4-methoxyben...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320065(Glycine, N-[(3S)-4-Benzyloxy-3-[[[((2S)-2-[(3-amin...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320057(ethyl 2-(4-(benzyloxy)-3-((S)-2-(5-bromofuran-2-ca...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320039(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(5-methoxy-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320046(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(1-methylcycl...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36592(FOS-70)
Affinity DataIC50: 3.5nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320041(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(2-chloro-5-(...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320042(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[((E)-3-(2,5-d...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36596(FOS-34)
Affinity DataIC50: 4nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Academia Sinica

LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 4nMAssay Description:To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320047(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(2,2-dimethyl...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320035(Glycine, N-[(3S)-4-Benzyloxy-3-[[[1-[(4-morpholiny...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Human)
Novartis Institutes

LigandPNGBDBM203827(WNK463 (2) | WNK463 | N-(tert-butyl)-1-(1-(5-(5-(t...)
Affinity DataIC50: 5nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50121549(N-((S)-1-((R)-2-(benzyloxy)-1-cyanoethylamino)-3-c...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320051(ethyl 2-(4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(3-me...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320060(ethyl 2-(4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(2-(n...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320064(Methyl 2-amino-4-([(1S)-2-(1-[(benzyloxy)methyl]-3...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320053(ethyl 2-(4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(2,3-...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Massachusetts Institute of Technology

LigandPNGBDBM36590(FOS-72)
Affinity DataIC50: 6nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase WNK1 [1-434](Human)
Novartis Institutes

LigandPNGBDBM203827(WNK463 (2) | WNK463 | N-(tert-butyl)-1-(1-(5-(5-(t...)
Affinity DataIC50: 6nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50121549(N-((S)-1-((R)-2-(benzyloxy)-1-cyanoethylamino)-3-c...)
Affinity DataIC50: 6nMAssay Description:Inhibition of cathepsin S in human B cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320058(ethyl 2-(4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(6-me...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320052(ethyl 2-(4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(4-me...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320056(ethyl 2-((S)-3-((S)-2-(2-amino-5-bromobenzamido)-3...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50320043(Glycine, N-[(3S)-4-benzyloxy-3-[[[2-[(2,3-dioxo-3-...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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