Compile Data Set for Download or QSAR
Found 1199 with Last Name = 'harbottle' and Initial = 'gw'
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197275(CHEMBL246023 | N-(2-(4-fluorophenyl)-2-methylpropy...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197248(CHEMBL246244 | N-(2-methyl-2-phenylpropyl)-5,6,7,8...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197249(CHEMBL245819 | N-(2-methyl-2-phenylpropyl)quinoxal...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197254(CHEMBL246250 | N-((1r,4r)-4-methylcyclohexyl)-5-(p...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278286(CHEMBL511266 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278407(CHEMBL470396 | N-cycloheptyl-6-(2-morpholinoethoxy...)
Affinity DataKi:  6nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197247(CHEMBL246251 | N-cycloheptyl-5-(piperidin-1-yl)pyr...)
Affinity DataKi:  8nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197268(5-(4-(hydroxymethyl)piperidin-1-yl)-N-((1r,4r)-4-m...)
Affinity DataKi:  9nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278361(CHEMBL471435 | N4-cyclohexyl-N6-(2-morpholinoethyl...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278289(CHEMBL469383 | N4-cyclohexyl-N6-(2-methoxyethyl)py...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197272(CHEMBL246245 | N-(2-methyl-2-phenylpropyl)-6-(pipe...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197276(5-((2-cyanoethyl)(methyl)amino)-N-(2-methyl-2-phen...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278112(CHEMBL472490 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-m...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197266(CHEMBL246024 | N-(2-methoxy-2-phenylpropyl)quinoxa...)
Affinity DataKi:  15nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197255(CHEMBL443489 | N-(2-methyl-2-phenylpropyl)-5-(pipe...)
Affinity DataKi:  17nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278358(1-(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-...)
Affinity DataKi:  20nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278232(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  21nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197265(CHEMBL241699 | N-(2-phenylpropyl)quinoxaline-2-car...)
Affinity DataKi:  22nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197270((R)-6-(2-hydroxy-1-phenylethylamino)-N-(2-methyl-2...)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197257(5-((1-(dimethylamino)propan-2-yl)(methyl)amino)-N-...)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278114(CHEMBL513012 | N-cyclohexylquinazolin-4-amine)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197251(6-(butyl(methyl)amino)-N-cycloheptylpyrazine-2-car...)
Affinity DataKi:  30nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278231(CHEMBL513018 | N4,N6-bis(2,3-dihydro-1H-inden-2-yl...)
Affinity DataKi:  31nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278357(3-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  33nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278153(CHEMBL471242 | N-(2,3-dihydro-1H-inden-2-yl)quinaz...)
Affinity DataKi:  34nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197264(5-(4-(hydroxymethyl)piperidin-1-yl)-N-(2-methyl-2-...)
Affinity DataKi:  35nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197262(CHEMBL246025 | N-(2-methyl-2-(pyridin-2-yl)propyl)...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197245(CHEMBL393681 | N-(2-methyl-1-phenylpropan-2-yl)qui...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197252(CHEMBL247485 | N-(2,3-dihydro-1H-inden-2-yl)-6-(et...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278362(CHEMBL512523 | N-cyclohexyl-6-(2-morpholinoethoxy)...)
Affinity DataKi:  42nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197267(6-((2-hydroxyethyl)(methyl)amino)-N-(2-methyl-2-ph...)
Affinity DataKi:  43nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197253(6-(3-hydroxyphenethylamino)-N-(cyclopropylmethyl)p...)
Affinity DataKi:  44nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278111(CHEMBL472489 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Affinity DataKi:  54nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197259(6-(4-benzyl-1,4-diazepan-1-yl)-N-(cyclopropylmethy...)
Affinity DataKi:  56nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197271(CHEMBL245820 | N-phenethylquinoxaline-2-carboxamid...)
Affinity DataKi:  69nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278291(CHEMBL471666 | N-cyclohexyl-6-(2-methoxyethoxy)pyr...)
Affinity DataKi:  101nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278287(CHEMBL469381 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Affinity DataKi:  102nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278113(CHEMBL513761 | N-(2,3-dihydro-1H-inden-2-yl)-6-met...)
Affinity DataKi:  115nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278229(2-(6-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197273((3-phenylpiperidin-1-yl)(quinoxalin-2-yl)methanone...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278228(CHEMBL447113 | N6-(2,3-dihydro-1H-inden-2-yl)-N4-m...)
Affinity DataKi:  160nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278290(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  177nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197258(CHEMBL247476 | N-(2-methyl-2-phenylpropyl)-5-pheny...)
Affinity DataKi:  179nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278853(CHEMBL496897 | N4-(2,3-dihydro-1H-inden-2-yl)-N6,N...)
Affinity DataKi:  185nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278850(CHEMBL497918 | N4-cyclohexyl-N6,N6-dimethylpyrido[...)
Affinity DataKi:  199nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278360(CHEMBL471434 | N6-(3-aminopropyl)-N4-cyclohexylpyr...)
Affinity DataKi:  200nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50278110(CHEMBL511838 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Affinity DataKi:  300nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197269(CHEMBL247475 | N-(2-methyl-2-phenylpropyl)-6-pheny...)
Affinity DataKi:  315nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50197274((8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-2...)
Affinity DataKi:  407nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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