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TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272395(N-(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272233(N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(4-fluoro-2-meth...)
Affinity DataEC50:  0.0890nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272234(3-(3-(2-Cyano-4-fluorophenyl)-1,2,4-oxadiazol-5-yl...)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at rat recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585763(CHEMBL5075328)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50375681(CHEMBL411630)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272346(N-(5-tert-Butylisoxazol-3-yl)-3-(3-(2-chloro-4-flu...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM17689(N-{4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phen...)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM50376025(AMG-0309 | CHEMBL409538)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376040(CHEMBL272824)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585766(CHEMBL5080866)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50376042(CHEMBL409512)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272233(N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(4-fluoro-2-meth...)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50376030(CHEMBL269916)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376036(CHEMBL270092)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376019(CHEMBL429585)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM21281(WIN55212-2 | CHEMBL188 | (2,3-dihydro-5-methyl-3-(...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50376026(CHEMBL272691)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272234(3-(3-(2-Cyano-4-fluorophenyl)-1,2,4-oxadiazol-5-yl...)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50375996(CHEMBL272250)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272274(N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(tetrahydro-2H-p...)
Affinity DataEC50:  0.380nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383200(CHEMBL2032026)
Affinity DataKi:  0.400nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272232(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272346(N-(5-tert-Butylisoxazol-3-yl)-3-(3-(2-chloro-4-flu...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272276(N-(6-Chloro-1,8-naphthyridin-3-yl)-3-(3-(2-chloro-...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataEC50:  0.430nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50375999(CHEMBL270342)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272233(N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(4-fluoro-2-meth...)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50376033(CHEMBL270985)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50376034(CHEMBL271563)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376035(AMG-6168 | CHEMBL411091)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50375679(CHEMBL270548)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272275(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM17703(N-(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]metho...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17704(N-(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]metho...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17705(N-{4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phen...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM50375690(CHEMBL270954)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM24466(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2008
Entry Details Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272232(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585759(CHEMBL5081712)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
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