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TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297677(N-benzyl-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297675(N-(4-fluorobenzyl)-4-(4-(methylsulfonyl)phenyl)-6-...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297669(N-cyclohexyl-4-(4-(methylsulfonyl)phenyl)-6-(trifl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042607((E)-(3R,5S)-7-[4,5-Bis-(4-fluoro-phenyl)-2-isoprop...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042625((E)-(3R,5S)-7-[2,4-Bis-(4-fluoro-phenyl)-5-isoprop...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042631(CHEMBL121727 | (E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297672(N-butyl-4-(4-(methylsulfonyl)phenyl)-6-(trifluorom...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297671(4-(2-(butylamino)-6-(trifluoromethyl)pyrimidin-4-y...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042615(CHEMBL332201 | (E)-(3R,5S)-7-[4-(4-Chloro-3,5-dime...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042614(Sodium; 7-[4,5-bis-(4-fluoro-phenyl)-2-isopropyl-i...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042620((E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-2-isopropyl-4-(...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281106((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281113(2,6-dihydroxy-7-methylcarbonyloxy-5-[3-(2-methyl-1...)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297670(N-sec-butyl-4-(4-(methylsulfonyl)phenyl)-6-(triflu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297668(4-(2-(cyclohexylamino)-6-(trifluoromethyl)pyrimidi...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042629(Sodium; 7-[3-(4-fluoro-phenyl)-5-isopropyl-2-pheny...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042622(CHEMBL431659 | (E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042601(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281105((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281109((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297664(N-methyl-4-(4-(methylsulfonyl)phenyl)-N-p-tolyl-6-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042612(Sodium; 7-[5-(4-fluoro-2-methyl-phenyl)-4-(4-fluor...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281102((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281101((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281119((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042611(Sodium; 3,5-dihydroxy-7-[6-hydroxy-2,8a-dimethyl-8...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051873((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article
PDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297665(4-(4-(methylsulfonyl)phenyl)-N-((tetrahydro-2H-pyr...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297673(4-(4-(methylsulfonyl)phenyl)-N-propyl-6-(trifluoro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297680(4-(4-(methylsulfonyl)phenyl)-N-phenyl-6-(trifluoro...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051872(2,6,7-trihydroxy-5-[3-(2-methyl-1-methylcarbonylox...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281122((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042616(CHEMBL122957 | (E)-(3R,5S)-7-[2-tert-Butyl-4,5-bis...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281106((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281116((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297678(N-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042643((E)-(3R,5S)-7-[5-(3-Chloro-phenyl)-4-(4-fluoro-phe...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281101((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281102((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281103((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281103((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281115((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297677(N-benzyl-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 8nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of lipopolysaccharide-stimulated PGE2 production after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042634((E)-(3R,5S)-7-[2-Dimethylamino-4,5-bis-(4-fluoro-p...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281116((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50281104((1S,3S,4S,5R,6R,7R)-7-Acetoxy-1-((4S,5R)-4-acetoxy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat liver squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281119((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297687(2-(cyclopentyloxy)-4-(4-(methylsulfonyl)phenyl)-6-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297684(2-(cyclooctyloxy)-4-(4-(methylsulfonyl)phenyl)-6-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297676(N-(4-methylbenzyl)-4-(4-(methylsulfonyl)phenyl)-6-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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