Compile Data Set for Download or QSAR
Found 299 with Last Name = 'hassler' and Initial = 'c'
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334454(CHEMBL1643895 | Ramosetron | US9045501, Ramosetron)
Show SMILES Cn1cc(C(=O)[C@@H]2CCc3nc[nH]c3C2)c2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM93624(5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4...)
Show SMILES Cc1nc[nH]c1CN1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM93624(5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4...)
Show SMILES Cc1nc[nH]c1CN1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329746(CHEMBL1271731 | endo-2-((3S,5S)-3,5-dimethylmorpho...)
Show SMILES C[C@H]1COC[C@H](C)N1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C23H32N4O3/c1-14-12-29-13-15(2)27(14)23-25-21-19(8-5-9-20(21)30-23)22(28)24-16-10-17-6-4-7-18(11-16)26(17)3/h5,8-9,14-18H,4,6-7,10-13H2,1-3H3,(H,24,28)/t14-,15-,17+,18+/m0/s1
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334442((S)-2-methyl-7-(quinuclidin-3-yl)-7,8-dihydropyraz...)
Show SMILES Cn1[nH]c2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C17H20N4O/c1-19-14-4-2-3-12-16(14)13(18-19)9-21(17(12)22)15-10-20-7-5-11(15)6-8-20/h2-4,9,11,15,18H,5-8,10H2,1H3/t15-/m1/s1
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334453((S)-5-methyl-2-(quinuclidin-3-yl)-2,3-dihydropyrro...)
Show SMILES Cn1cc2CN([C@@H]3CN4CCC3CC4)C(=O)c3cccc1c23
Show InChI InChI=1S/C18H21N3O/c1-19-9-13-10-21(16-11-20-7-5-12(16)6-8-20)18(22)14-3-2-4-15(19)17(13)14/h2-4,9,12,16H,5-8,10-11H2,1H3/t16-/m1/s1
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334452((R)-5-methyl-2-(quinuclidin-3-yl)-2,3-dihydropyrro...)
Show SMILES Cn1cc2CN([C@H]3CN4CCC3CC4)C(=O)c3cccc1c23
Show InChI InChI=1S/C18H21N3O/c1-19-9-13-10-21(16-11-20-7-5-12(16)6-8-20)18(22)14-3-2-4-15(19)17(13)14/h2-4,9,12,16H,5-8,10-11H2,1H3/t16-/m0/s1
Affinity DataKi:  0.900nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329748(CHEMBL1271791 | endo-2-((3S,5S)-3-ethyl-5-methylmo...)
Show SMILES CC[C@H]1COC[C@H](C)N1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C24H34N4O3/c1-4-17-14-30-13-15(2)28(17)24-26-22-20(9-6-10-21(22)31-24)23(29)25-16-11-18-7-5-8-19(12-16)27(18)3/h6,9-10,15-19H,4-5,7-8,11-14H2,1-3H3,(H,25,29)/t15-,17-,18+,19+/m0/s1
Affinity DataKi:  1nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334445((S)-2-ethyl-7-(quinuclidin-3-yl)-7,8-dihydropyrazo...)
Show SMILES CCn1[nH]c2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C18H22N4O/c1-2-22-15-5-3-4-13-17(15)14(19-22)10-21(18(13)23)16-11-20-8-6-12(16)7-9-20/h3-5,10,12,16,19H,2,6-9,11H2,1H3/t16-/m1/s1
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334439((R)-2-methyl-7-(quinuclidin-3-yl)-7,8-dihydropyraz...)
Show SMILES Cn1[nH]c2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C17H20N4O/c1-19-14-4-2-3-12-16(14)13(18-19)9-21(17(12)22)15-10-20-7-5-11(15)6-8-20/h2-4,9,11,15,18H,5-8,10H2,1H3/t15-/m0/s1
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334443((R)-4-fluoro-2-methyl-7-(quinuclidin-3-yl)-7,8-dih...)
Show SMILES Cn1[nH]c2cn([C@H]3CN4CCC3CC4)c(=O)c3cc(F)cc1c23
Show InChI InChI=1S/C17H19FN4O/c1-20-14-7-11(18)6-12-16(14)13(19-20)8-22(17(12)23)15-9-21-4-2-10(15)3-5-21/h6-8,10,15,19H,2-5,9H2,1H3/t15-/m0/s1
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334444((R)-2-ethyl-7-(quinuclidin-3-yl)-7,8-dihydropyrazo...)
Show SMILES CCn1[nH]c2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C18H22N4O/c1-2-22-15-5-3-4-13-17(15)14(19-22)10-21(18(13)23)16-11-20-8-6-12(16)7-9-20/h3-5,10,12,16,19H,2,6-9,11H2,1H3/t16-/m0/s1
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329745(CHEMBL1271730 | endo-2-((S)-3-tert-butylmorpholino...)
Show SMILES CN1[C@@H]2CCC[C@@H]1CC(C2)NC(=O)c1cccc2oc(nc12)N1CCOC[C@@H]1C(C)(C)C
Show InChI InChI=1S/C25H36N4O3/c1-25(2,3)21-15-31-12-11-29(21)24-27-22-19(9-6-10-20(22)32-24)23(30)26-16-13-17-7-5-8-18(14-16)28(17)4/h6,9-10,16-18,21H,5,7-8,11-15H2,1-4H3,(H,26,30)/t17-,18-,21-/m1/s1
Affinity DataKi:  2nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334447((S)-2-isopropyl-7-(quinuclidin-3-yl)-7,8-dihydropy...)
Show SMILES CC(C)n1[nH]c2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C19H24N4O/c1-12(2)23-16-5-3-4-14-18(16)15(20-23)10-22(19(14)24)17-11-21-8-6-13(17)7-9-21/h3-5,10,12-13,17,20H,6-9,11H2,1-2H3/t17-/m1/s1
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334448((S)-2-isobutyl-7-(quinuclidin-3-yl)-7,8-dihydropyr...)
Show SMILES CC(C)Cn1[nH]c2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C20H26N4O/c1-13(2)10-24-17-5-3-4-15-19(17)16(21-24)11-23(20(15)25)18-12-22-8-6-14(18)7-9-22/h3-5,11,13-14,18,21H,6-10,12H2,1-2H3/t18-/m1/s1
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329724(CHEMBL1271960 | endo-2-((2S,6S)-2,6-dimethylpipera...)
Show SMILES C[C@H]1CNC[C@H](C)N1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C23H33N5O2/c1-14-12-24-13-15(2)28(14)23-26-21-19(8-5-9-20(21)30-23)22(29)25-16-10-17-6-4-7-18(11-16)27(17)3/h5,8-9,14-18,24H,4,6-7,10-13H2,1-3H3,(H,25,29)/t14-,15-,17+,18+/m0/s1
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329744(CHEMBL1271678 | endo-2-((S)-3-isobutylmorpholino)-...)
Show SMILES CC(C)C[C@H]1COCCN1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C25H36N4O3/c1-16(2)12-20-15-31-11-10-29(20)25-27-23-21(8-5-9-22(23)32-25)24(30)26-17-13-18-6-4-7-19(14-17)28(18)3/h5,8-9,16-20H,4,6-7,10-15H2,1-3H3,(H,26,30)/t18-,19-,20+/m1/s1
Affinity DataKi:  3.5nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334446((R)-2-isopropyl-7-(quinuclidin-3-yl)-7,8-dihydropy...)
Show SMILES CC(C)n1[nH]c2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C19H24N4O/c1-12(2)23-16-5-3-4-14-18(16)15(20-23)10-22(19(14)24)17-11-21-8-6-13(17)7-9-21/h3-5,10,12-13,17,20H,6-9,11H2,1-2H3/t17-/m0/s1
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus (rat))
AMRI

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
Affinity DataKi:  3.90nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329742(CHEMBL1271629 | endo-N-((1R,5R)-9-methyl-9-azabicy...)
Show SMILES CCC[C@H]1COCCN1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C24H34N4O3/c1-3-6-19-15-30-12-11-28(19)24-26-22-20(9-5-10-21(22)31-24)23(29)25-16-13-17-7-4-8-18(14-16)27(17)2/h5,9-10,16-19H,3-4,6-8,11-15H2,1-2H3,(H,25,29)/t17-,18-,19+/m1/s1
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334440((R)-7-(quinuclidin-3-yl)-7,8-dihydropyrazolo[3,4,5...)
Show SMILES O=c1n(cc2[nH][nH]c3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H18N4O/c21-16-11-2-1-3-12-15(11)13(18-17-12)8-20(16)14-9-19-6-4-10(14)5-7-19/h1-3,8,10,14,17-18H,4-7,9H2/t14-/m0/s1
Affinity DataKi:  4.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401743(CHEMBL2206526)
Show SMILES CN1CC(c2ccc(C)c(F)c2)c2ccccc2C1
Show InChI InChI=1S/C17H18FN/c1-12-7-8-13(9-17(12)18)16-11-19(2)10-14-5-3-4-6-15(14)16/h3-9,16H,10-11H2,1-2H3
Affinity DataKi:  4.40nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329741(CHEMBL1271628 | endo-2-((S)-3-ethylmorpholino)-N-(...)
Show SMILES CC[C@H]1COCCN1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C23H32N4O3/c1-3-16-14-29-11-10-27(16)23-25-21-19(8-5-9-20(21)30-23)22(28)24-15-12-17-6-4-7-18(13-15)26(17)2/h5,8-9,15-18H,3-4,6-7,10-14H2,1-2H3,(H,24,28)/t16-,17+,18+/m0/s1
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329730((S)-2-amino-6-chloro-N-(quinuclidin-3-yl)benzo[d]o...)
Show SMILES Nc1nc2c(cc(Cl)cc2o1)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H17ClN4O2/c16-9-5-10(13-12(6-9)22-15(17)19-13)14(21)18-11-7-20-3-1-8(11)2-4-20/h5-6,8,11H,1-4,7H2,(H2,17,19)(H,18,21)/t11-/m1/s1
Affinity DataKi:  4.70nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334441((S)-7-(quinuclidin-3-yl)-7,8-dihydropyrazolo[3,4,5...)
Show SMILES O=c1n(cc2[nH][nH]c3cccc1c23)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H18N4O/c21-16-11-2-1-3-12-15(11)13(18-17-12)8-20(16)14-9-19-6-4-10(14)5-7-19/h1-3,8,10,14,17-18H,4-7,9H2/t14-/m1/s1
Affinity DataKi:  4.90nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329743(CHEMBL1271677 | endo-2-((S)-3-isopropylmorpholino)...)
Show SMILES CC(C)[C@H]1COCCN1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C24H34N4O3/c1-15(2)20-14-30-11-10-28(20)24-26-22-19(8-5-9-21(22)31-24)23(29)25-16-12-17-6-4-7-18(13-16)27(17)3/h5,8-9,15-18,20H,4,6-7,10-14H2,1-3H3,(H,25,29)/t17-,18-,20-/m1/s1
Affinity DataKi:  5nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401732(CHEMBL2206507)
Show SMILES CN1CC(c2cccc(Cl)c2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H18ClN/c1-12-6-7-16-14(8-12)10-19(2)11-17(16)13-4-3-5-15(18)9-13/h3-9,17H,10-11H2,1-2H3
Affinity DataKi:  5nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401731(CHEMBL2206508)
Show SMILES CN1CC(c2cc(F)cc(F)c2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H17F2N/c1-11-3-4-16-13(5-11)9-20(2)10-17(16)12-6-14(18)8-15(19)7-12/h3-8,17H,9-10H2,1-2H3
Affinity DataKi:  5.80nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
Affinity DataKi:  5.97nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus (rat))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Show SMILES CN1C[C@@H](c2ccc(F)cc2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H18FN/c1-12-3-8-16-14(9-12)10-19(2)11-17(16)13-4-6-15(18)7-5-13/h3-9,17H,10-11H2,1-2H3/t17-/m0/s1
Affinity DataKi:  6.30nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329747(2-((3S,5S)-3,5-dimethylmorpholino)-N-((S)-quinucli...)
Show SMILES C[C@H]1COC[C@H](C)N1c1nc2c(cccc2o1)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C21H28N4O3/c1-13-11-27-12-14(2)25(13)21-23-19-16(4-3-5-18(19)28-21)20(26)22-17-10-24-8-6-15(17)7-9-24/h3-5,13-15,17H,6-12H2,1-2H3,(H,22,26)/t13-,14-,17+/m0/s1
Affinity DataKi:  6.80nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Show SMILES CN1C[C@@H](c2ccc(F)cc2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H18FN/c1-12-3-8-16-14(9-12)10-19(2)11-17(16)13-4-6-15(18)7-5-13/h3-9,17H,10-11H2,1-2H3/t17-/m0/s1
Affinity DataKi:  7.10nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334449((R)-2-benzyl-7-(quinuclidin-3-yl)-7,8-dihydropyraz...)
Show SMILES O=c1n(cc2[nH]n(Cc3ccccc3)c3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C23H24N4O/c28-23-18-7-4-8-20-22(18)19(24-27(20)13-16-5-2-1-3-6-16)14-26(23)21-15-25-11-9-17(21)10-12-25/h1-8,14,17,21,24H,9-13,15H2/t21-/m0/s1
Affinity DataKi:  7.10nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401744(CHEMBL2206525)
Show SMILES CN1CC(c2ccc(Cl)c(F)c2)c2ccccc2C1
Show InChI InChI=1S/C16H15ClFN/c1-19-9-12-4-2-3-5-13(12)14(10-19)11-6-7-15(17)16(18)8-11/h2-8,14H,9-10H2,1H3
Affinity DataKi:  7.20nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401737(CHEMBL2206532)
Show SMILES COc1ccc2C(CN(C)Cc2c1)c1cccc(C)c1
Show InChI InChI=1S/C18H21NO/c1-13-5-4-6-14(9-13)18-12-19(2)11-15-10-16(20-3)7-8-17(15)18/h4-10,18H,11-12H2,1-3H3
Affinity DataKi:  7.30nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Show SMILES CN1CC(c2ccc(F)cc2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H18FN/c1-12-3-8-16-14(9-12)10-19(2)11-17(16)13-4-6-15(18)7-5-13/h3-9,17H,10-11H2,1-2H3
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50334451((S)-2-(4-fluorophenyl)-7-(quinuclidin-3-yl)-7,8-di...)
Show SMILES Fc1ccc(cc1)-n1[nH]c2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23
Show InChI InChI=1S/C22H21FN4O/c23-15-4-6-16(7-5-15)27-19-3-1-2-17-21(19)18(24-27)12-26(22(17)28)20-13-25-10-8-14(20)9-11-25/h1-7,12,14,20,24H,8-11,13H2/t20-/m1/s1
Affinity DataKi:  7.90nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329728(CHEMBL1272073 | endo-2-cyclopropyl-N-((1R,5R)-9-me...)
Show SMILES CN1[C@@H]2CCC[C@@H]1CC(C2)NC(=O)c1cccc2oc(nc12)C1CC1
Show InChI InChI=1S/C20H25N3O2/c1-23-14-4-2-5-15(23)11-13(10-14)21-19(24)16-6-3-7-17-18(16)22-20(25-17)12-8-9-12/h3,6-7,12-15H,2,4-5,8-11H2,1H3,(H,21,24)/t14-,15-/m1/s1
Affinity DataKi:  8.30nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401738(CHEMBL2206531)
Show SMILES COc1ccc2C(CN(C)Cc2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H17F2NO/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11/h3-8,15H,9-10H2,1-2H3
Affinity DataKi:  9nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401740(CHEMBL2206529)
Show SMILES CN1CC(c2ccc(C)cc2)c2cccc(C)c2C1
Show InChI InChI=1S/C18H21N/c1-13-7-9-15(10-8-13)18-12-19(3)11-17-14(2)5-4-6-16(17)18/h4-10,18H,11-12H2,1-3H3
Affinity DataKi:  10.6nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401716(CHEMBL2206524)
Show SMILES CN1CC(c2ccc(F)c(F)c2)c2ccccc2C1
Show InChI InChI=1S/C16H15F2N/c1-19-9-12-4-2-3-5-13(12)14(10-19)11-6-7-15(17)16(18)8-11/h2-8,14H,9-10H2,1H3
Affinity DataKi:  12.3nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329754((S)-2-(diethylamino)-N-(quinuclidin-3-yl)benzo[d]o...)
Show SMILES CCN(CC)c1nc2c(cccc2o1)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H26N4O2/c1-3-23(4-2)19-21-17-14(6-5-7-16(17)25-19)18(24)20-15-12-22-10-8-13(15)9-11-22/h5-7,13,15H,3-4,8-12H2,1-2H3,(H,20,24)/t15-/m1/s1
Affinity DataKi:  12.4nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329739(CHEMBL1271570 | endo-N-(8-methyl-8-azabicyclo[3.2....)
Show SMILES C[C@H]1COCCN1c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C22H30N4O3/c1-14-13-28-10-9-26(14)22-24-20-18(7-4-8-19(20)29-22)21(27)23-15-11-16-5-3-6-17(12-15)25(16)2/h4,7-8,14-17H,3,5-6,9-13H2,1-2H3,(H,23,27)/t14-,16+,17+/m0/s1
Affinity DataKi:  12.9nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401735(CHEMBL2206534)
Show SMILES CN1CC(c2ccc(F)c(F)c2)c2ccc(O)cc2C1
Show InChI InChI=1S/C16H15F2NO/c1-19-8-11-6-12(20)3-4-13(11)14(9-19)10-2-5-15(17)16(18)7-10/h2-7,14,20H,8-9H2,1H3
Affinity DataKi:  13nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401742(CHEMBL2206527)
Show SMILES CN1CC(c2ccc(F)c(C)c2)c2ccccc2C1
Show InChI InChI=1S/C17H18FN/c1-12-9-13(7-8-17(12)18)16-11-19(2)10-14-5-3-4-6-15(14)16/h3-9,16H,10-11H2,1-2H3
Affinity DataKi:  13.5nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329729((S)-2-amino-N-(quinuclidin-3-yl)benzo[d]oxazole-4-...)
Show SMILES Nc1nc2c(cccc2o1)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H18N4O2/c16-15-18-13-10(2-1-3-12(13)21-15)14(20)17-11-8-19-6-4-9(11)5-7-19/h1-3,9,11H,4-8H2,(H2,16,18)(H,17,20)/t11-/m1/s1
Affinity DataKi:  13.8nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401733(CHEMBL2206536)
Show SMILES CN1CC(c2ccc(F)c(F)c2)c2ccc(C)cc2C1
Show InChI InChI=1S/C17H17F2N/c1-11-3-5-14-13(7-11)9-20(2)10-15(14)12-4-6-16(18)17(19)8-12/h3-8,15H,9-10H2,1-2H3
Affinity DataKi:  14nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50329726(CHEMBL1272017 | endo-2-(2-methoxyphenyl)-N-((1R,5R...)
Show SMILES COc1ccccc1-c1nc2c(cccc2o1)C(=O)NC1C[C@H]2CCC[C@H](C1)N2C
Show InChI InChI=1S/C24H27N3O3/c1-27-16-7-5-8-17(27)14-15(13-16)25-23(28)19-10-6-12-21-22(19)26-24(30-21)18-9-3-4-11-20(18)29-2/h3-4,6,9-12,15-17H,5,7-8,13-14H2,1-2H3,(H,25,28)/t16-,17-/m1/s1
Affinity DataKi:  14.9nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
AMRI

Curated by ChEMBL
LigandPNGBDBM50401734(CHEMBL2206535)
Show SMILES CN1CC(c2ccc(C)cc2)c2ccc(C)cc2C1
Show InChI InChI=1S/C18H21N/c1-13-4-7-15(8-5-13)18-12-19(3)11-16-10-14(2)6-9-17(16)18/h4-10,18H,11-12H2,1-3H3
Affinity DataKi:  15nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
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