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TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.00800nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.0400nMAssay Description:Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287890(CHEMBL427778 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.0770nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071445(CHEMBL310039 | N-[(R)-1-[(S)-2-Ethenesulfonylamino...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071438((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071423(CHEMBL72924 | N-[(R)-1-[(S)-2-(2-Ethoxy-ethanesulf...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071435((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071437(CHEMBL308102 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071436(CHEMBL306950 | N-[(R)-1-[(S)-2-(Butane-1-sulfonyla...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071420(CHEMBL72348 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287885(CHEMBL405377 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.25nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071421(CHEMBL310920 | N-[(R)-1-[(S)-2-Benzenesulfonylamin...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071430(CHEMBL73373 | N-[(R)-1-[(S)-2-Ethanesulfonylamino-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071439(CHEMBL73000 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071428(CHEMBL307471 | N-[(R)-1-{(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071444(CHEMBL307045 | N-[(R)-1-[1-(Butane-1-sulfonylamino...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071443(CHEMBL308269 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071440(CHEMBL307384 | N-[(R)-1-[2-(Butane-1-sulfonylamino...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071432((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071426(CHEMBL73835 | N-[(R)-1-[1-(Butane-1-sulfonylaminoc...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071441((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071427((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.790nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071437(CHEMBL308102 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  0.890nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287883(CHEMBL412003 | Suc-Glu-Ala-Gly-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.910nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50071433((S)-2-{(R)-3-Biphenyl-4-yl-2-[(3,5-dimethyl-benzoy...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071433((S)-2-{(R)-3-Biphenyl-4-yl-2-[(3,5-dimethyl-benzoy...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287882(CHEMBL412065 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-Gly-Leu...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071425(CHEMBL311854 | N-[(R)-1-[(S)-1-(Butane-1-sulfonyla...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071425(CHEMBL311854 | N-[(R)-1-[(S)-1-(Butane-1-sulfonyla...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for the binding affinity against Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071434(CHEMBL72217 | N-[(R)-1-[1-(Butane-1-sulfonylaminoc...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071425(CHEMBL311854 | N-[(R)-1-[(S)-1-(Butane-1-sulfonyla...)
Affinity DataKi:  1.5nMAssay Description:Compound was tested for the binding affinity against Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071425(CHEMBL311854 | N-[(R)-1-[(S)-1-(Butane-1-sulfonyla...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071445(CHEMBL310039 | N-[(R)-1-[(S)-2-Ethenesulfonylamino...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071420(CHEMBL72348 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071421(CHEMBL310920 | N-[(R)-1-[(S)-2-Benzenesulfonylamin...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071436(CHEMBL306950 | N-[(R)-1-[(S)-2-(Butane-1-sulfonyla...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071442(CHEMBL72358 | N-[(R)-1-[2-(Butane-1-sulfonylamino)...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071440(CHEMBL307384 | N-[(R)-1-[2-(Butane-1-sulfonylamino...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071424(CHEMBL263301 | N-[(R)-1-[1-(Butane-1-sulfonylamino...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071422(CHEMBL73042 | N-[(R)-1-[1-(Butane-1-sulfonylaminoc...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071428(CHEMBL307471 | N-[(R)-1-{(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071429((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287878(CGP-49941 | CHEMBL305615 | N-{(R)-1-[2-(1H-Indol-3...)
Affinity DataKi:  5nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071444(CHEMBL307045 | N-[(R)-1-[1-(Butane-1-sulfonylamino...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071430(CHEMBL73373 | N-[(R)-1-[(S)-2-Ethanesulfonylamino-...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287888(CHEMBL407559 | Suc-Glu-Ala-Val-Tyr-Phe-Gly-His-Leu...)
Affinity DataKi:  5.30nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071443(CHEMBL308269 | N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethy...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50071426(CHEMBL73835 | N-[(R)-1-[1-(Butane-1-sulfonylaminoc...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287886(CHEMBL405796 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Gly...)
Affinity DataKi:  5.90nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  6nM ΔG°:  -47.7kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
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