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TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50259548(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]PGE2 from EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183182(2''-benzyloxy-5''-chloro-[1,1';2',1'']terphenyl-3-...)
Affinity DataKi:  31.6nMAssay Description:Antagonist activity at EP1 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412231(CHEMBL520438)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412241(CHEMBL495091)
Affinity DataKi:  50.1nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412239(CHEMBL492237)
Affinity DataKi:  79.4nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412232(CHEMBL523216)
Affinity DataKi:  79.4nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412224(CHEMBL479591)
Affinity DataKi:  79.4nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain and PHD finger-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  100nMAssay Description:Binding affinity to human partial length BRPF3 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412209(CHEMBL494466)
Affinity DataKi:  100nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412233(CHEMBL495107)
Affinity DataKi:  100nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412225(CHEMBL480789)
Affinity DataKi:  126nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412208(CHEMBL493254)
Affinity DataKi:  126nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412215(CHEMBL481870)
Affinity DataKi:  158nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412213(CHEMBL481689)
Affinity DataKi:  158nMAssay Description:Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50259548(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
Affinity DataKi:  316nMAssay Description:Binding affinity to TP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50259548(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
Affinity DataKi:  2.00E+3nMAssay Description:Activity at EP3 receptor by FLIPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413672(CHEMBL516324)
Affinity DataIC50:  2nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413670(CHEMBL458452)
Affinity DataIC50:  3.98nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413667(CHEMBL514574)
Affinity DataIC50:  3.98nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419265(CHEMBL1835069)
Affinity DataIC50:  4nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412237(CHEMBL492238)
Affinity DataIC50:  5.01nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413668(CHEMBL457142)
Affinity DataIC50:  5.01nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412231(CHEMBL520438)
Affinity DataIC50:  6.31nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412236(CHEMBL494282)
Affinity DataIC50:  6.31nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413673(CHEMBL456496)
Affinity DataIC50:  6.31nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412235(CHEMBL493065)
Affinity DataIC50:  6.31nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412229(CHEMBL480950)
Affinity DataIC50:  7.94nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412239(CHEMBL492237)
Affinity DataIC50:  7.94nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412238(CHEMBL523158)
Affinity DataIC50:  7.94nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412234(CHEMBL523679)
Affinity DataIC50:  7.94nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413669(CHEMBL515981)
Affinity DataIC50:  10nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413671(CHEMBL458448)
Affinity DataIC50:  10nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419258(CHEMBL1835070)
Affinity DataIC50:  10nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412226(CHEMBL404525)
Affinity DataIC50:  10nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412224(CHEMBL479591)
Affinity DataIC50:  10nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413674(CHEMBL456495)
Affinity DataIC50:  10nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413663(CHEMBL466549)
Affinity DataIC50:  12.6nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412227(CHEMBL480181)
Affinity DataIC50:  12.6nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412216(CHEMBL447709)
Affinity DataIC50:  12.6nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412225(CHEMBL480789)
Affinity DataIC50:  12.6nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412228(CHEMBL479989)
Affinity DataIC50:  12.6nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412230(CHEMBL480790)
Affinity DataIC50:  12.6nMAssay Description:Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50259548(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
Affinity DataIC50:  12.6nMAssay Description:Binding affinity to rat EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419256(CHEMBL1835065 | US9579320, Example 302)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50:  13nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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