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TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288345(CHEMBL4159139)
Affinity DataEC50:  678nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM8125(Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...)
Affinity DataEC50:  13nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/V82I mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288347(CHEMBL4160986)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288356(CHEMBL4168317)
Affinity DataEC50:  165nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288359(CHEMBL4164025)
Affinity DataEC50:  61nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288360(CHEMBL4163344)
Affinity DataEC50:  95nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288362(CHEMBL4160405)
Affinity DataEC50:  226nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288363(CHEMBL4173216)
Affinity DataEC50:  25nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50180655(CHEBI:31781 | A-157378-0 | A-157378.0 | ABT-378 | ...)
Affinity DataEC50:  1.16E+3nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288363(CHEMBL4173216)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/V82I mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288363(CHEMBL4173216)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/I84V mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM8125(Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...)
Affinity DataEC50:  112nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/I84V mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288364(CHEMBL4160695)
Affinity DataEC50:  84nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50288365(CHEMBL4165197)
Affinity DataEC50:  309nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM580(AG1776 | (4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2...)
Affinity DataEC50:  2.73E+3nMAssay Description:Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50482142(KPU-244-B3 | CHEMBL1096312)
Affinity DataKd:  2.52E+4nMAssay Description:Binding affinity to pig tubulin after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity to pig tubulin after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50482143(KPU-244-B2 | CHEMBL1077255)
Affinity DataKd:  9.74E+3nMAssay Description:Binding affinity to pig tubulin after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50483308(CHEMBL1643852)
Affinity DataKd:  1.79E+4nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50014846(7alphaH-colchicine | (S)-N-(5,6,7,9-tetrahydro-1,2...)
Affinity DataKd:  3.70E+3nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454212(CHEBI:64217 | Emonapride | Nemonapride)
Affinity DataKd:  0.210nMAssay Description:Binding Affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478722(KNI-1933 | CHEMBL452953)
Affinity DataIC50: 0.0830nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478719(KNI-1965 | CHEMBL509400)
Affinity DataIC50: 0.0860nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478712(KNI-1969 | CHEMBL485911)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478713(KNI-1961 | CHEMBL510136)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478715(KNI-1910 | CHEMBL452873)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478721(KNI-1931 | CHEMBL230484)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478714(KNI-1909 | CHEMBL462726)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478718(KNI-1932 | CHEMBL455816)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478720(KNI-1960 | CHEMBL508278)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478716(KNI-1878 | CHEMBL449836)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 6(Rhesus macaque)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50463591(CHEMBL4248604)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of monkey CCR6 expressed in CHO cells assessed as decrease in CCL20-induced reduction of forskolin-stimulated cAMP accumulation preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50478717(KNI-1876 | CHEMBL503829)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandPNGBDBM50090510(CHEMBL3581716)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182869(N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(3,5-di(...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182869(N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(3,5-di(...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182869(N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(3,5-di(...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50090666(CHEMBL3581717)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090665(CHEMBL3581718)
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090648(CHEMBL3581732)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090687(CHEMBL3581715)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090514(CHEMBL3581736)
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090617(CHEMBL3581734)
Affinity DataIC50: 3.10nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50188338(N-((S)-3-((S)-1-((S)-1-((2S,3R)-4-(3-(2H-tetrazol-...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50188338(N-((S)-3-((S)-1-((S)-1-((2S,3R)-4-(3-(2H-tetrazol-...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50141551(5-[(S)-3-((S)-2-{(S)-2-[2-Amino-3-((S)-carboxyamin...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration of compound against Beta-secretase 1 was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50090650(CHEMBL3581730)
Affinity DataIC50: 3.40nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090616(CHEMBL3581735)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50090656(CHEMBL3581724)
Affinity DataIC50: 3.70nMAssay Description:In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
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