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TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50123490(CHEMBL143418 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50123496(CHEMBL143138 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50067797(CHEMBL19080 | L-37378 | N-(6-Amino-2-methyl-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50123500(CHEMBL143139 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50173944(5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 3A(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173944(5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,...)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT3A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130216(CHEMBL3632874)
Affinity DataKi:  5nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130256(CHEMBL3632875)
Affinity DataKi:  8nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCannabinoid receptor 1(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130307(CHEMBL3633035)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP55940 from mouse brain membrane CB1 receptor after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130296(CHEMBL3632876)
Affinity DataKi:  15nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50400862(CHEMBL2205015)
Affinity DataKi:  19nMAssay Description:Inhibition of FKBP12 (unknown origin)-mediated rotamase activity by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCannabinoid receptor 1(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130306(CHEMBL3633034)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP55940 from mouse brain membrane CB1 receptor after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211195(CHEMBL3944506)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130213(CHEMBL3632871)
Affinity DataKi:  57nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130215(CHEMBL3632873)
Affinity DataKi:  65nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50164613((-)-Spiro[1-azabicyclo(2.2.2)octane-3,5'-oxazolidi...)
Affinity DataKi:  92nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat hippocampal alpha7 nAChR measured after 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130211(CHEMBL3632869)
Affinity DataKi:  270nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130212(CHEMBL3632870)
Affinity DataKi:  360nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130214(CHEMBL3632872)
Affinity DataKi:  590nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130309(CHEMBL3633037)
Affinity DataKi:  2.40E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130310(CHEMBL3633038)
Affinity DataKi:  2.80E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130308(CHEMBL3633036)
Affinity DataKi:  8.40E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target4-aminobutyrate aminotransferase, mitochondrial(Pig)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50082127(3-(ammoniomethyl)-2,6-difluorobenzenolate | 3-Amin...)
Affinity DataKi:  6.30E+6nMAssay Description:Competitive inhibition of pig brain GABA aminotransferase by Dixon/Cornish-Bowden plot analysis in presence of GABAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target4-aminobutyrate aminotransferase, mitochondrial(Pig)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50073151(4-(ammoniomethyl)-2,6-difluorobenzenolate | 4-Amin...)
Affinity DataKi:  1.10E+7nMAssay Description:Competitive inhibition of pig brain GABA aminotransferase by Dixon/Cornish-Bowden plot analysis in presence of GABAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1D(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.140nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297163(2-{8-Fluoro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(2-{7-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1D(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50065419(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445527(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445528(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-6-fluoro-5-[...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDipeptidyl peptidase 4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130304(CHEMBL3632865)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50566615(CHEMBL4846895)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579852(CHEMBL5090513)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579851(CHEMBL5084198)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(2-{7-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM296947(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-5-[oxan-4-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445515(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-9-fluoro-5-[...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDipeptidyl peptidase 4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50130302(CHEMBL3632867)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445527(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM297236(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-methoxy-5-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

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