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TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169541(CHEMBL3805542)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174392(US9688669, Example 124)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174258(US9688669, Example 89)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174255(US9688669, Example 86)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174267(US9688669, Example 98)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174275(US9688669, Example 108)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174391(US9688669, Example 123)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM168300(US9688669, Example 99)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174277(US9688669, Example 110)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174252(US9688669, Example 83)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174306(US9688669, Example 120)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174266(US9688669, Example 97)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174276(US9688669, Example 109)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174282(US9688669, Example 115)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174257(US9688669, Example 88)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174284(US9688669, Example 117)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174331(US9688669, Example 121)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174263(US9688669, Example 94)
Affinity DataKi:  259nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174264(US9688669, Example 95)
Affinity DataKi:  323nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174262(US9688669, Example 93)
Affinity DataKi:  372nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174273(US9688669, Example 105)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174270(US9688669, Example 102)
Affinity DataKi:  580nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174271(US9688669, Example 103)
Affinity DataKi:  710nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174272(US9688669, Example 104)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174265(US9688669, Example 96)
Affinity DataKi:  1.67E+3nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM179971(US9688669, Example 106)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM174269(US9688669, Example 101)
Affinity DataKi:  5.00E+3nMAssay Description:Displacement of [3H]MPEPy from human mGluR5 expressed in cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM32416(furan-2-carboxamide deriv., 28)
Affinity DataIC50:  2nMpH: 7.5 T: 37°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325334((S)-N-(3-(5-(2-(methylamino)-2-oxo-1-(tetrahydro-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325338((S)-N-(3-(5-(2-(methylamino)-2-oxo-1-(tetrahydro-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169542(CHEMBL3804846)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-MethoxyPEPy from mGlu5 receptor in primary rat astrocytes after 8 hrs by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin G(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50349174(CHEMBL1807526)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Princeton University

Curated by ChEMBL
LigandPNGBDBM50625784(CHEMBL5428267)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity to human ROR1 expressed in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325342((R)-2-chloro-N-(3-(5-(1-cyclohexyl-2-(methylamino)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169542(CHEMBL3804846)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-MethoxyPEPy from human mGlu5 receptor expressed in HEK293 cell membranes after 8 hrs by micro beta scintillation counting analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325347((R)-N-(3-(5-(1-cyclohexyl-2-(methylamino)-2-oxoeth...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM32417(furan-2-carboxamide deriv., 29)
Affinity DataIC50:  4nMpH: 7.5 T: 37°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin G(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50349176(CHEMBL1807531)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325333((S)-N-(3-(5-(3-hydroxy-3-methyl-1-(methylamino)-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Princeton University

Curated by ChEMBL
LigandPNGBDBM50625783(CHEMBL5399065)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity to human ROR1 expressed in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Princeton University

Curated by ChEMBL
LigandPNGBDBM50625782(CHEMBL5397895)
Affinity DataIC50:  5.30nMAssay Description:Binding affinity to human ROR1 expressed in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM32412(furan-2-carboxamide deriv., 24)
Affinity DataIC50:  6nMpH: 7.5 T: 37°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325340((S)-N-(3-(5-(3-methyl-1-(methylamino)-1-oxobutan-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM32414(furan-2-carboxamide deriv., 26)
Affinity DataIC50:  6nMpH: 7.5 T: 37°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Princeton University

Curated by ChEMBL
LigandPNGBDBM50625781(CHEMBL5427174)
Affinity DataIC50:  6.30nMAssay Description:Binding affinity to human ROR1 expressed in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetCathepsin G(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50349173(CHEMBL1807638)
Affinity DataIC50:  7nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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