Compile Data Set for Download or QSAR
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TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423441(WO2005113580-Ex-43)
Affinity DataEC50:  5.90E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423428(WO2005113580-Ex-26)
Affinity DataEC50:  5.80E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423442(WO2005113580-Ex-44)
Affinity DataEC50:  5.30E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423450(WO2005113580-Ex-52)
Affinity DataEC50:  1.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423429(WO2005113580-Ex-27)
Affinity DataEC50:  1.40E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423430(WO2005113580-Ex-28)
Affinity DataEC50:  1.60E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423449(WO2005113580-Ex-51)
Affinity DataEC50:  3.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423448(WO2005113580-Ex-50)
Affinity DataEC50:  3.20E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataEC50:  200nMAssay Description:Inhibition of XO44 binding to CDK2 in human KURAMOCHI cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataEC50:  9nMAssay Description:Inhibition of XO44 binding to CDK2 in human HCC1806 cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423413(WO2005113580-Ex-07)
Affinity DataEC50: >4.20E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423469(WO2006061714-ID-14 | WO2006061714, P39.4 | cmdc.20...)
Affinity DataEC50:  1.80E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423414(WO2005113580-Ex-08 | cmdc.202100576, 24c)
Affinity DataEC50:  1.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423432(WO2005113580-Ex-30)
Affinity DataEC50:  4.10E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423427(WO2005113580-Ex-25)
Affinity DataEC50:  3.90E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423443(WO2005113580-Ex-45)
Affinity DataEC50:  5.30E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423422(WO2005113580-Ex-18)
Affinity DataEC50:  2.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423434(WO2005113580-Ex-36)
Affinity DataEC50:  6.70E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423463(WO2006061714-ID-07)
Affinity DataEC50:  9.15E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetRetinoblastoma-associated protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataEC50:  19nMAssay Description:Inhibition of RB1 phosphorylation in human OVCAR-3 cells assessed as reduction in phosphorylation at Serine 807/811 residue incubated for 1 hr by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423459(WO2006061714-ID-01 | WO2006061714, Example 1)
Affinity DataEC50: >1.00E+5nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423458(WO2005113580-Ex-61)
Affinity DataEC50: >1.00E+5nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423435(WO2005113580-Ex-37 | cmdc.202100576, 24e)
Affinity DataEC50:  9.30E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423455(WO2005113580-Ex-57)
Affinity DataEC50:  2.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataEC50:  597nMAssay Description:Inhibition of XO44 binding to CDK1 in human HCC1806 cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423420(WO2005113580-Ex-16 | cmdc.202100576, 24b)
Affinity DataEC50:  1.70E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of XO44 binding to CDK1 in human KURAMOCHI cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataEC50:  5.10E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423417(WO2005113580-Ex-11)
Affinity DataEC50:  5.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510049('WO2021205298, Compound 49 | (3S)-3-({N-[(4-methox...)
Affinity DataEC50:  144nMAssay Description:The ability of compounds to protect cells against infection by SARS-CoV-2 is measured by a cell viability assay similar to that described in Weislow,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021205298

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423466(WO2006061714-ID-11 | WO2006061714, P39.1 | cmdc.20...)
Affinity DataEC50:  2.50E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423412(WO2005113580-Ex-06)
Affinity DataEC50:  4.50E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423419(WO2005113580-Ex-14)
Affinity DataEC50:  3.20E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423440(WO2005113580-Ex-42)
Affinity DataEC50:  5.90E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423454(WO2005113580-Ex-56)
Affinity DataEC50: >1.00E+5nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423446(WO2005113580-Ex-48)
Affinity DataEC50:  1.40E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423425(WO2005113580-Ex-22)
Affinity DataEC50:  7.50E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423436(WO2005113580-Ex-38)
Affinity DataEC50:  5.40E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423426(WO2005113580-Ex-23 | cmdc.202100576, 6e)
Affinity DataEC50:  4.70E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423421(WO2005113580-Ex-17)
Affinity DataEC50:  4.60E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423424(WO2005113580-Ex-21)
Affinity DataEC50: >1.00E+5nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423418(WO2005113580-Ex-13)
Affinity DataEC50:  1.10E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423408(WO2005113580-Ex-01 | US11753373, Compound A-5-c)
Affinity DataEC50:  1.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423444(WO2005113580-Ex-46)
Affinity DataEC50:  350nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423465(WO2006061714-ID-10 | WO2006061714, P38.8 | cmdc.20...)
Affinity DataEC50:  4.20E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  74nMAssay Description:The ability of compounds to protect cells against infection by SARS-CoV-2 is measured by a cell viability assay similar to that described in Weislow,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021205298

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423457(WO2005113580-Ex-58)
Affinity DataEC50: >1.00E+5nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423415(WO2005113580-Ex-10)
Affinity DataEC50:  3.30E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423423(WO2005113580-Ex-20)
Affinity DataEC50:  2.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423410(WO2005113580-Ex-03 | cmdc.202100576, 6d)
Affinity DataEC50:  3.10E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

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