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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to human mTOR after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  0.880nMAssay Description:Binding affinity to human PI3Kalpha after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  18nMAssay Description:Binding affinity to human PI3Kalpha diluted 30 fold and equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  80nMAssay Description:Binding affinity to human PI3Kgamma diluted 30 fold and equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to human PI3Kalpha after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 1 hr followed by 30 fold dilution and re-equilibrate for 5 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  0.430nMAssay Description:Binding affinity to human PI3Kalpha equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  10nMAssay Description:Binding affinity to human mTOR after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to human LCK after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  15nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to human PI3Kbeta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  0.560nMAssay Description:Binding affinity to human PI3Kalpha equilibrate for 1 hr followed by 30 fold dilution and re-equilibrate for 5 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  0.650nMAssay Description:Binding affinity to human PI3Kalpha equilibrate for 1 hr by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  2nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 1 hr by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to human PI3Kbeta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKd:  0.840nMAssay Description:Binding affinity to wild-type human partial length PIK3CA (R108 to N1068 residues) expressed in mammalian expression system by quantitative PCR based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in mammalian expression system by quantitative PCR based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50449568(CHEMBL2448558)
Affinity DataKd:  3.20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKd:  0.813nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82561(TROPANYL 3,5-DICHLOROBENZOATE | CAS_40796-97-2 | T...)
Affinity DataKd:  6.20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-Piperazin-1-yl-quinoline (Quipazine) | CHEMBL187...)
Affinity DataKd:  2nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKd:  13nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50227350(NORTROPISETRON | SDZ-206-792)
Affinity DataKd:  0.724nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50227348(CHEMBL41096 | SDZ-206-830)
Affinity DataKd:  0.158nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM48320(SMR000058471 | METOCLOPRAMIDE | METOCLOPRAMIDE HYD...)
Affinity DataKd:  224nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Mouse)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50000483(CHEMBL519643 | 1-Methyl-1H-indazole-3-carboxylic a...)
Affinity DataKd:  1.40nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50062446(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Affinity DataIC50: 1.40nMAssay Description:Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50280609(2-[6-(1-Ethyl-pyrrolidin-2-ylamino)-4-methyl-pyrid...)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280589((+)-(1-Ethyl-pyrrolidin-2-yl)-(6-phenyl-5-propyl-p...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280589((+)-(1-Ethyl-pyrrolidin-2-yl)-(6-phenyl-5-propyl-p...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

Target5-hydroxytryptamine receptor 3A/3B(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50062449(1-(4-Methyl-piperazin-1-yl)-phthalazine; hydrochlo...)
Affinity DataIC50: 10nMAssay Description:Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement of [3H]granisetron from rat cerebral cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50280599(N*2*,N*2*-Diethyl-N*1*-(6-isobutyl-5-phenyl-pyrida...)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280612((1-Ethyl-pyrrolidin-2-yl)-(6-methyl-5-phenyl-pyrid...)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280589((+)-(1-Ethyl-pyrrolidin-2-yl)-(6-phenyl-5-propyl-p...)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

Target5-hydroxytryptamine receptor 3A/3B(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50062451(3-(4-Methyl-piperazin-1-yl)-5-phenyl-pyridazine; h...)
Affinity DataIC50: 36nMAssay Description:Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement of [3H]granisetron from rat cerebral cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50280587(N*1*-(5,6-Diphenyl-pyridazin-3-yl)-N*2*,N*2*-dieth...)
Affinity DataIC50: 40nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280605(N*2*,N*2*-Diethyl-2-methyl-N*1*-(5-phenyl-6-propyl...)
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280617(N'-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyri...)
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280583(N*2*,N*2*-Diethyl-2-methyl-N*1*-(6-phenyl-5-propyl...)
Affinity DataIC50: 110nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280582(2-[6-(2-Diethylamino-2-methyl-propylamino)-4-propy...)
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280603(N,N-Dimethyl-N'-(2-methyl-biphenyl-4-yl)-ethane-1,...)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280616((5,6-Diphenyl-pyridazin-3-yl)-(2-morpholin-4-yl-et...)
Affinity DataIC50: 170nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280588(N*2*,N*2*-Diethyl-2-methyl-N*1*-(6-methyl-5-phenyl...)
Affinity DataIC50: 180nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280614(N,N-Dimethyl-N'-(4-methyl-6-phenyl-pyridazin-3-yl)...)
Affinity DataIC50: 230nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280586(2-[6-(2-Diethylamino-2-methyl-propylamino)-4-methy...)
Affinity DataIC50: 240nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50280594(N'-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyri...)
Affinity DataIC50: 240nMAssay Description:Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

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