Compile Data Set for Download or QSAR
Found 258 with Last Name = 'hu' and Initial = 'yj'
TargetPeptide deformylase(Escherichia coli (strain K12))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50291695(CHEMBL84822 | H-PHOSPHONATE DERIVATIVE)
Affinity DataKi:  3.70E+4nMAssay Description:Compound was evaluated for inhibitory activity against Peptide deformylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Escherichia coli (strain K12))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50071663(CHEMBL309477 | H-PHOSPHONATE DERIVATIVE)
Affinity DataKi:  1.25E+5nMAssay Description:Compound was evaluated for inhibitory activity against Peptide deformylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50507479(CHEMBL4447260)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27707(4-{1-[3-(8-chloro-4-oxo-3,4-dihydroquinazolin-2-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165496(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50507479(CHEMBL4447260)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165488(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165498(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165478(1-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27708(8-chloro-2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahyd...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340753(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27709(2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165472(1-(2-chloro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165477(CHEMBL371425 | N-(3-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340743(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27705(2-[3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)prop...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340744(CHEMBL1762699 | N-benzyl-2-(4-(2-(4-chlorophenethy...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379718(CHEMBL2011127)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50220868(2-(3-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379717(CHEMBL2011126)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340745(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379716(CHEMBL2011125)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50120265(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255501(3-(2,4-dioxo-2,3,4,5,7,8-hexahydro-1H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255360(1-Phenethyl-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255630(5-methyl-N-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165484(1-(2-methoxy-5-((4-oxo-3,4-dihydrophthalazin-1-yl)...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165474(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379714(CHEMBL2011123)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340746(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50507479(CHEMBL4447260)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255572(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255502(2-(2-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)ethyl)p...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165483(CHEMBL381208 | N-Ethyl-3-(4-oxo-3,4-dihydro-phthal...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataIC50:  55nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50165471(CHEMBL196507 | Cyclopropanecarboxylic acid [3-(4-o...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50240980(CHEMBL372450 | N-(3-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379707(CHEMBL2011112)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108048((E)-2-(3,5-dimethoxystyryl)thiophene | 2-[(E)-2-(3...)
Affinity DataIC50:  61nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50255411(1-[4-(3-Dimethylamino-propoxy)-phenyl]-8,9-dihydro...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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