Compile Data Set for Download or QSAR
Report error Found 563 with Last Name = 'huffman' and Initial = 'wf'
LigandPNGBDBM50020686(CHEMBL278188 | 4-(2-Amino-ethyl)-7-hydroxy-1,3-dih...)
Affinity DataEC50:  116nMAssay Description:Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 3 ug/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(CHEMBL587 | 7-Hydroxy Ropinirole | 4-(2-Dipropylam...)
Affinity DataEC50:  1.80nMAssay Description:Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 0.3 mg/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50019389(CHEMBL130795 | 3-Allyl-6-chloro-1-(4-hydroxy-pheny...)
Affinity DataEC50:  122nMAssay Description:Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 0.3 mg/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50019396(CHEMBL15564 | 4-(2-Dipropylamino-ethyl)-benzene-1,...)
Affinity DataEC50:  80nMAssay Description:Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 3 mg/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2018
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Smith Kline and French Laboratories

Curated by ChEMBL
LigandPNGBDBM50228042(CHEMBL323548)
Affinity DataIC50: 0.0187nMAssay Description:Agonistic activity for opioid receptor deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316497(N-{4-[1-(2,3-Dihydroxypropyl)-4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316473(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316475(N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-pyrrolidinylmeth...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316471(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316492(1-(4-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316498(N-{4-[1-(3-Hydroxypropyl)-4-(1H-pyrrolo[2,3-b]pyri...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316474(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083763([(S)-8-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-3-o...)
Affinity DataIC50: 3nMAssay Description:HEK cell adhesion mediated by alpha v beta 3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316496(N-{4-[1-(2-Hydroxyethyl)-4-(1H-pyrrolo[2,3-b]pyrid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316470(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316472(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316476(N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolidinylmethyl)pheny...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316479((4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316478(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(N-[3-fluoro-4'-(trifluoromethyl)-4-biphenylyl]sulf...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316483(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316481(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316477(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataIC50: 6.5nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316482(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316480(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220195(N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea | CH...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316509(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083761([3-Oxo-8-[3-(pyridin-2-ylamino)-propoxy]-2-(2,2,2-...)
Affinity DataIC50: 12nMAssay Description:HEK cell adhesion mediated by alpha v beta 3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220159(N-[3'-fluoro-4'-(trifluoromethyl)-4-biphenylyl]sul...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316495(N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 17nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220182(N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | C...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50: 20nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316505(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316488(N-(4-{1-Ethyl-4-[2-({[2-(4-morpholinyl)ethyl]amino...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316509(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316507(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316479((4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220201(N-[3-amino-4'-(trifluoromethyl)-4-biphenylyl]sulfa...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316487(N-(4-{1-Ethyl-4-[2-({[2-(methylsulfonyl)ethyl]amin...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316491(N-{4-[1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315772(N'-{4-[1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316508(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220155(N-[3'-nitro-4'-(trifluoromethyl)-4-biphenylyl]sulf...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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