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TargetAngiotensin-converting enzyme(Human)
Mrc Laboratory of Molecular Biology, Hills Road, Cambridge, Cb2 2Qh

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataEC50:  1.42E+6nMAssay Description:Inhibition of human ACE Y1096F mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Mrc Laboratory of Molecular Biology, Hills Road, Cambridge, Cb2 2Qh

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataEC50:  1.85E+4nMAssay Description:Inhibition of human ACE K1087A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Mrc Laboratory of Molecular Biology, Hills Road, Cambridge, Cb2 2Qh

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataEC50:  2.12E+4nMAssay Description:Inhibition of human ACE C domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Jamia Hamdard (Hamdard University)

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CDK2/cyclin A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218973(CHEMBL44001)
Affinity DataIC50: 8.32nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524139(CHEMBL4467602)
Affinity DataIC50: 10nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524135(CHEMBL4570349)
Affinity DataIC50: 20nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524140(CHEMBL4447483)
Affinity DataIC50: 30nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50143486(N-Acetyl-4-[4-(4-methanesulfonyl-phenyl)-5-oxo-2,5...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGF2alpha production incubated for 15 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218964(CHEMBL44223)
Affinity DataIC50: 132nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127653(1-(4-Methanesulfonyl-phenyl)-4,5-dihydro-3aH-napht...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127652(1-(4-Methanesulfonyl-phenyl)-8-methyl-4,5-dihydro-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Guinea pig)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 600nMAssay Description:Inhibition of COX2 in guinea pig blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 640nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524136(CHEMBL4553594)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125626(5-Hydroxy-4-(4-methanesulfonyl-phenyl)-5-methyl-3-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50297560(3-[5-(3,4-Dimethoxy phenyl)-1,3,4-oxadiazol-2-yl]-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTyrosinase(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50219502(4-hydroxyphenyl beta-D-glucopyranoside | hydroquin...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125624(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methanesulfonyl...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM233052(3-(2,6-Dichlorobenzylidene)-5-(4-isobutylphenyl)-2...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50297559(3-[5-(4-Methoxyophenyl)-1,3,4-oxadiazol-2-yl]-1-(b...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM233053(3-(2,4-Dichlorobenzylidene)-5-(4-isobutylphenyl)-2...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM233050(3-(2-Chlorobenzylidene)-5-(4-isobutylphenyl)-2(3H)...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50297561(3-[(5-(2-Naphthoxymethyl)-1,3,4-oxadiazol-2-yl)-1-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rabbit)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of COX2 in rabbit whole blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524137(CHEMBL4452147)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50235073(CHEMBL4098802)
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM233051(3-(4-Fluorobenzylidene)-5-(4-isobutylphenyl)-2(3H)...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Jamia Hamdard (Hamdard University)

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 3.87E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50235072(CHEMBL4070457)
Affinity DataIC50: 6.93E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50297558(3-[5-(4-Nitrophenyl)-1,3,4-oxadiazol-2-yl]-1-(biph...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50235074(CHEMBL4100043)
Affinity DataIC50: 9.58E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human COX2 expressed in CHO cells cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Jamia Hamdard (Hamdard University)

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human COX2 expressed in human osteosarcoma cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.31E+4nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50297558(3-[5-(4-Nitrophenyl)-1,3,4-oxadiazol-2-yl]-1-(biph...)
Affinity DataIC50: 4.26E+4nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM233052(3-(2,6-Dichlorobenzylidene)-5-(4-isobutylphenyl)-2...)
Affinity DataIC50: 4.76E+4nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM233053(3-(2,4-Dichlorobenzylidene)-5-(4-isobutylphenyl)-2...)
Affinity DataIC50: 4.82E+4nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50297561(3-[(5-(2-Naphthoxymethyl)-1,3,4-oxadiazol-2-yl)-1-...)
Affinity DataIC50: 4.84E+4nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTyrosinase(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524138(CHEBI:74456 | CHEMBL3182150)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50297559(3-[5-(4-Methoxyophenyl)-1,3,4-oxadiazol-2-yl]-1-(b...)
Affinity DataIC50: 5.23E+4nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM233050(3-(2-Chlorobenzylidene)-5-(4-isobutylphenyl)-2(3H)...)
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of the enzymes was determined using an enzyme immunoassay (EIA) kit (catalog no. 560101, Cayman Chemical, Ann Arbor, MI, USA) according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
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