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TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50150068(CHEMBL3775323)
Affinity DataKd:  6.80E+3nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  2.50E+5nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50038879(JTP-4819 | CHEMBL79993 | (S)-2-(2-Formyl-pyrrolidi...)
Affinity DataIC50: 1.27nMAssay Description:Inhibition of Flavobacterium meningosepticum propyl endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50: 13nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM311486(US10155764, Example 65B | CHEM-US-00192)
Affinity DataIC50: 19nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataIC50: 40nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032927(PFI-4 | PFI 4 | PFI4 | N-[2,3-Dihydro-1,3-dimethyl...)
Affinity DataIC50: 50nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataIC50: 60nMAssay Description:Displacement of Halo-tagged histone H3.3 from NanoLuc-tagged full length human PCAF bromodomain expressed in HEK293 cells after 18 hrs by NanoBRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataIC50: 63nMAssay Description:Displacement of Halo-tagged histone H3.3 from NanoLuc-tagged full length human PCAF bromodomain expressed in HEK293 cells after 18 hrs by NanoBRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234931(CHEMBL4088595)
Affinity DataIC50: 70nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234939(CHEMBL4084253)
Affinity DataIC50: 79nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032912(CHEMBL1522313)
Affinity DataIC50: 79nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032918(CHEMBL3356140)
Affinity DataIC50: 100nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032917(CHEMBL1724375)
Affinity DataIC50: 100nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032924(CHEMBL1396002)
Affinity DataIC50: 126nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032928(CHEMBL3356145)
Affinity DataIC50: 126nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032921(CHEMBL1444120)
Affinity DataIC50: 200nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234926(CHEMBL4101945)
Affinity DataIC50: 300nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032922(CHEMBL1701516)
Affinity DataIC50: 316nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032916(CHEMBL1357836)
Affinity DataIC50: 316nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234926(CHEMBL4101945)
Affinity DataIC50: 316nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032914(CHEMBL3356142)
Affinity DataIC50: 398nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Affinity DataIC50: 501nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032909(CHEMBL1361770)
Affinity DataIC50: 631nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032915(CHEMBL3356141)
Affinity DataIC50: 631nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032920(CHEMBL3356138)
Affinity DataIC50: 631nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032923(CHEMBL3356144)
Affinity DataIC50: 794nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234930(CHEMBL4070058)
Affinity DataIC50: 900nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032912(CHEMBL1522313)
Affinity DataIC50: 980nMAssay Description:Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032912(CHEMBL1522313)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234940(CHEMBL4101756)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234925(CHEMBL4096572)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234943(CHEMBL4099456 | US10239861, Example 3)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032919(CHEMBL3356139)
Affinity DataIC50: 1.59E+3nMAssay Description:Binding affinity to 6His-tagged-BRD4 BD1 Y390A mutant (1 to 477 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032925(CHEMBL3356146)
Affinity DataIC50: 1.59E+3nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50398244(CHEMBL609728)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234926(CHEMBL4101945)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234926(CHEMBL4101945)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032921(CHEMBL1444120)
Affinity DataIC50: 2.51E+3nMAssay Description:Binding affinity to 6His-tagged-BRD4 BD1 Y390A mutant (1 to 477 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032926(CHEMBL1702128)
Affinity DataIC50: 2.51E+3nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234924(CHEMBL4065579)
Affinity DataIC50: 2.51E+3nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032910(CHEMBL3356147)
Affinity DataIC50: 3.16E+3nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032911(CHEMBL1535485)
Affinity DataIC50: 3.16E+3nMAssay Description:Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032912(CHEMBL1522313)
Affinity DataIC50: 3.16E+3nMAssay Description:Binding affinity to 6-His-tagged-BRD4 (1 to 477 aa) Y97A mutant (unknown origin) by TR-FRET competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234945(CHEMBL4061142 | US10239861, Example 59)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234925(CHEMBL4096572)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234936(CHEMBL4074202)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234935(CHEMBL4075248)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234937(CHEMBL4100959)
Affinity DataIC50: 7.94E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataIC50: 7.94E+3nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
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