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TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578106(CHEMBL4868777)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578107(CHEMBL4845931)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578108(CHEMBL4878248)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578109(CHEMBL4863880)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578110(CHEMBL4845867)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578111(CHEMBL4861425)
Affinity DataEC50:  0.0130nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578112(CHEMBL4856084)
Affinity DataEC50:  0.590nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578113(CHEMBL4854239)
Affinity DataEC50:  0.210nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578114(CHEMBL4862717)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578115(CHEMBL4856293)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578116(CHEMBL4862497)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578117(CHEMBL4854548)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578118(CHEMBL4870834)
Affinity DataEC50:  0.0410nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578119(CHEMBL4851978)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578120(CHEMBL4858892)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578121(CHEMBL4860633)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578122(CHEMBL4849848)
Affinity DataEC50:  0.0140nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578123(CHEMBL4872591)
Affinity DataEC50:  0.0130nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578124(CHEMBL4866325)
Affinity DataEC50:  0.0130nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578125(CHEMBL4878917)
Affinity DataEC50:  0.0810nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578126(CHEMBL4853282)
Affinity DataEC50:  0.0190nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578127(CHEMBL4876263)
Affinity DataEC50:  0.0780nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578128(CHEMBL4873269)
Affinity DataEC50:  0.0170nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578129(CHEMBL4862195)
Affinity DataEC50:  0.0480nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272772(CHEMBL1680 | 10-(4-Amino-butyl)-19-(2-amino-3-phen...)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50578130(CHEMBL4863622)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human SSTR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104905(CHEMBL3597618)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104904(CHEMBL3597617)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104883(CHEMBL3597616)
Affinity DataIC50: 0.470nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104872(CHEMBL3597535)
Affinity DataIC50: 0.560nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104864(CHEMBL3597527)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104910(CHEMBL3597623)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104869(CHEMBL3597532)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 2(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104905(CHEMBL3597618)
Affinity DataIC50: 0.880nMAssay Description:Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 2(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104883(CHEMBL3597616)
Affinity DataIC50: 0.890nMAssay Description:Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104839(CHEMBL3597525)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 2(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104867(CHEMBL3597530)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335414(US9732085, 391 | 4-(2-{(3S)-8-chloro-7-[5-chloro-2...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335416(US9732085, 399 | 5-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335414(US9732085, 391 | 4-(2-{(3S)-8-chloro-7-[5-chloro-2...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335416(US9732085, 399 | 5-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104871(CHEMBL3597534)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104920(CHEMBL3597633)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US9585881, Example 99 | methyl [4-(2-{(2S,4S)-1-[(...)
Affinity DataIC50: 1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238267(US9394250, 99)
Affinity DataIC50: 1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US9585881, Example 99 | methyl [4-(2-{(2S,4S)-1-[(...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US9585881, Example 99 | methyl [4-(2-{(2S,4S)-1-[(...)
Affinity DataIC50: 1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335412(US9732085, 363 | 4-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335412(US9732085, 363 | 4-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.40nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335399(US9732085, 198 | (3S)-3-[5-(6-amino-3-pyridinyl)-4...)
Affinity DataIC50: 1.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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