Compile Data Set for Download or QSAR
Found 551 with Last Name = 'innis' and Initial = 'rb'
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.00800nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.00900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50066789(3-((S)-1-Azetidin-2-ylmethoxy)-5-iodo-pyridine | A...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50066789(3-((S)-1-Azetidin-2-ylmethoxy)-5-iodo-pyridine | A...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160893(8-Methyl-3-(4-thiophen-3-yl-phenyl)-8-aza-bicyclo[...)
Affinity DataKi:  0.0170nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50100712(2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptan...)
Affinity DataKi:  0.0200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50106857(3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-car...)
Affinity DataKi:  0.0620nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400876(CHEMBL2204347)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229593(CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...)
Affinity DataKi:  0.0978nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400875(CHEMBL2204353)
Affinity DataKi:  0.101nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400874(CHEMBL2086410)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50100712(2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptan...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160892(3-(4-Thiophen-2-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Yale University

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.120nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400873(CHEMBL2088029)
Affinity DataKi:  0.137nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160894(8-Methyl-3-(4-thiophen-2-yl-phenyl)-8-aza-bicyclo[...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400872(CHEMBL2088033)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175644(CHEMBL200044 | methyl 3-(4-(furan-2-yl)phenyl)-8-a...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50107863((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50255877(CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50107863((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160898(3-(4-Thiophen-3-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400871(CHEMBL2088030)
Affinity DataKi:  0.231nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Displacement of [3H]PK11195 from human PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400870(CHEMBL559569 | SB-612111)
Affinity DataKi:  0.253nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
Yale University

Curated by ChEMBL
LigandPNGBDBM50088753(5-(3-Bromo-phenyl)-8-chloro-3-methyl-2,3,4,5-tetra...)
Affinity DataKi:  0.260nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335260(CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.299nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113332(3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2-t...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335259(CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175634(CHEMBL200698 | methyl 3-(4-(furan-3-yl)phenyl)-8-m...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50095027((2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-eth...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160895(3-[4-(5-Bromo-thiophen-2-yl)-phenyl]-8-methyl-8-az...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50383117(CHEMBL2031737)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175646(3-(3',5'-difluoro-biphenyl-4-yl)-8-methyl-8-aza-bi...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]cyanoimipramine from SERT in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.460nMAssay Description:Affinity for Serotonin transporter by displacing [3H]-Paroxetine from rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Yale School of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity to dopamine transporter in membranes of cells selectively expressing the human genes for DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175640(3-(3'-fluoro-biphenyl-4-yl)-8-methyl-8-aza-bicyclo...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113325((4-Fluoro-phenyl)-{1-[2-(3-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  0.510nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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