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TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataKi:  4.32E+3nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088513(CHEMBL3526940)
Affinity DataKi:  2.48E+4nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088514(CHEBI:88735 | CHEMBL3526740)
Affinity DataKi:  3.55E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50003616(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Affinity DataKi:  3.63E+5nMAssay Description:Inhibition of human CES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088516(CHEMBL3526990)
Affinity DataKi:  4.68E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088515(CHEMBL3526991)
Affinity DataKi:  7.07E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50003616(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Affinity DataKi:  7.90E+6nMAssay Description:Inhibition of human CES2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26339((2R,3E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  0.120nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  0.120nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304410(CHEMBL594108 | cis-2-[(E)-4-(1H-Imidazol-1-yl)but-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304411(CHEMBL594109 | cis-2-{4-[(1H-Imidazol-1-yl)methyl]...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26338((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  0.710nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336911((S)-2-((S)-2-((S)-5-amino-2-((S)-1-((S)-2-((S)-2-(...)
Affinity DataIC50:  0.790nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304412(CHEMBL595064 | cis-4-(3,4-Dimethoxyphenyl)-2-{4-[(...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304423(CHEMBL595272 | cis-4-(3,4-Dimethoxyphenyl)-2-[4-(m...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598881(CHEMBL5194905)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304419(CHEMBL592931 | cis-4-(3,4-Dimethoxyphenyl)-2-[2-(m...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304413(CHEMBL596447 | cis-2-[4-(1,4-Dioxa-8-azaspiro[4.5]...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304418(CHEMBL596394 | cis-4-(3,4-Dimethoxyphenyl)-2-[3-(m...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336911((S)-2-((S)-2-((S)-5-amino-2-((S)-1-((S)-2-((S)-2-(...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304415(CHEMBL595038 | cis-4-(3,4-Dimethoxyphenyl)-2-{4-[(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304422(CHEMBL605096 | cis-5-(3,4-Dimethoxyphenyl)-3-[4-(m...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  4.70nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304409(CHEMBL595959 | cis-2-{2-[2-(1H-Imidazol-1-yl)ethox...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304414(CHEMBL603626 | cis-4-(3,4-Dimethoxyphenyl)-2-[4-(p...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304416(CHEMBL595039 | cis-4-(3,4-Dimethoxyphenyl)-2-{4-[(...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304408(CHEMBL605935 | N-[3-(1H-Imidazol-1-yl)propyl]-2-[c...)
Affinity DataIC50:  14.3nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598880(CHEMBL5187248)
Affinity DataIC50:  16nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304421(CHEMBL603194 | cis-5-(3,4-Dimethoxyphenyl)-3-[4-(m...)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304420(6-(3,4-Dimethoxyphenyl)-2-[4-(morpholinomethyl)ben...)
Affinity DataIC50:  45.9nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  76nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598878(CHEMBL5174146)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598882(CHEMBL5178360)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuropeptide FF receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26338((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  160nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598884(CHEMBL5191549)
Affinity DataIC50:  160nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598889(CHEMBL5186497)
Affinity DataIC50:  270nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598891(CHEMBL5200510)
Affinity DataIC50:  390nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598881(CHEMBL5194905)
Affinity DataIC50:  400nMAssay Description:Inhibition of NNMT in HEK293 cells measured after 20 to 24 hrs by RapidFire Mass SpectrometryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptide FF receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26339((2R,3E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  640nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336912(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Affinity DataIC50:  830nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26338((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  1.96E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 30 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598883(CHEMBL5182917)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  2.27E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 60 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26339((2R,3E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  2.51E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 10 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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