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TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataEC50:  89nMAssay Description:Agonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50004796(CHEMBL292418 | CHEMBL540857 | 8-Chloro-5-phenyl-2,...)
Affinity DataEC50:  40nMAssay Description:Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  167nMAssay Description:Agonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  359nMAssay Description:Agonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  9.50E+3nMAssay Description:Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  254nMAssay Description:Agonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250795(CHEMBL4084262)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50454212(CHEBI:64217 | Emonapride | Nemonapride)
Affinity DataIC50: 98nMAssay Description:Antagonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as inhibition of lisuride-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataIC50: 328nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250795(CHEMBL4084262)
Affinity DataIC50: 1.62E+3nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [125I]IABN from recombinant human D2 long receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [125I]ABN from human dopamine D2 long receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to dopamine D4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of D4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor transiently expressed in CHO cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525056(CHEMBL4525842)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method relative to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250795(CHEMBL4084262)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250795(CHEMBL4084262)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250795(CHEMBL4084262)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50512808(CHEMBL4438361)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250797(CHEMBL4062553)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250797(CHEMBL4062553)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525051(CHEMBL4459784)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50039791(1-Butyl-4-(2-methoxy-phenyl)-piperazine | CHEMBL26...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]IABN from recombinant human D2 long receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50512808(CHEMBL4438361)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]IABN from recombinant human D2 long receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50039791(1-Butyl-4-(2-methoxy-phenyl)-piperazine | CHEMBL26...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250799(CHEMBL4076516)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525034(CHEMBL4549664)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250807(CHEMBL4073927)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525057(CHEMBL4534961)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250807(CHEMBL4073927)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525043(CHEMBL4476163)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525036(CHEMBL4438524)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525040(CHEMBL4471201)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525023(CHEMBL4535104)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50525024(CHEMBL4475482)
Affinity DataKi:  45nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1A adrenergic receptor measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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