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TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537560(CHEMBL427101)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537561(CHEMBL388502)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537562(CHEMBL223720)
Affinity DataKd:  720nMAssay Description:Binding affinity to HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407454(CHEMBL5281526)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50495950(Danoprevir | R-05190591 | R05190591 | RO-5190591 |...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537589(CHEMBL4287268)
Affinity DataIC50: 3nMAssay Description:Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407449(CHEMBL5285995)
Affinity DataIC50: 3nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537581(CHEMBL4638107)
Affinity DataIC50: 4nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407495(CHEMBL5286471)
Affinity DataIC50: 4nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537583(CHEMBL4638630)
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537585(CHEMBL4646449)
Affinity DataIC50: 5nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDNA polymerase beta(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407496(CHEMBL5284382)
Affinity DataIC50: 5nMAssay Description:Inhibition of human DNA polymerase beta by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537579(CHEMBL4635161)
Affinity DataIC50: 6nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537587(CHEMBL4633142)
Affinity DataIC50: 6nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537578(CHEMBL245328)
Affinity DataIC50: 7.20nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: 8nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407448(CHEMBL4454956)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537574(CHEMBL4643906)
Affinity DataIC50: 10nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537575(CHEMBL4638877)
Affinity DataIC50: 10nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407495(CHEMBL5286471)
Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/Cyclin D1 (Q4 to I295 residues) expressed in sf9 cells using RBCTF a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537588(CHEMBL4643189)
Affinity DataIC50: 17nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) using RBER-CHKtide as substrate measured after 1 hr by ADP-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50081635(CHEMBL3422107)
Affinity DataIC50: 19nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50142061(2-{4-[4''-Chloro-4-(4-hydroxy-piperidine-1-carbony...)
Affinity DataIC50: 19nMAssay Description:Binding affinity to HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407494(CHEMBL5276118)
Affinity DataIC50: 25nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537580(CHEMBL480816)
Affinity DataIC50: 27nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407452(CHEMBL5284923)
Affinity DataIC50: 30nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537566(CHEMBL4640558)
Affinity DataIC50: 33nMAssay Description:Inhibition of HCV NS3/4a proteaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard (Hamdard University)

LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 36nMAssay Description:The COX activity was assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-pphenylenediamine (TMPD) at 590 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537586(CHEMBL4641917)
Affinity DataIC50: 39nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537571(CHEMBL390883)
Affinity DataIC50: 42nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407494(CHEMBL5276118)
Affinity DataIC50: 46nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407454(CHEMBL5281526)
Affinity DataIC50: 49nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537565(CHEMBL4649647)
Affinity DataIC50: 51nMAssay Description:Inhibition of HCV NS3/4a proteaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537584(CHEMBL4636786)
Affinity DataIC50: 53nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50187149(6-cyclohexyl-4-(2-(dimethylamino)-2-oxoethyl)-5-ph...)
Affinity DataIC50: 58nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537582(CHEMBL1783101)
Affinity DataIC50: 70nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407450(CHEMBL4544901)
Affinity DataIC50: 97nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50137504(1-Cyclohexyl-2-furan-2-yl-1H-benzoimidazole-5-carb...)
Affinity DataIC50: 160nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407451(CHEMBL5270628)
Affinity DataIC50: 188nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537572(CHEMBL1087567)
Affinity DataIC50: 300nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407447(CHEMBL5285729)
Affinity DataIC50: 303nMAssay Description:Inhibition of EBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50537576(CHEMBL4633554)
Affinity DataIC50: 340nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50370763(CHEMBL1203926)
Affinity DataIC50: 340nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50536931(CHEMBL4578017)
Affinity DataIC50: 470nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/Cyclin D1 (Q4 to I295 residues) expressed in sf9 cells using RBCTF a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50160199(6,7-Bis-(4-fluoro-phenyl)-pteridin-4-ol | CHEMBL18...)
Affinity DataIC50: 500nMAssay Description:Binding affinity to HCV NS5A polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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