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TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401097(CHEMBL2204469)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to human CRTH2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401116(CHEMBL2204474)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006915(CHEMBL3236929)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006823(CHEMBL3236950)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401097(CHEMBL2204469)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CRTH2 receptor-mediated chemotaxis in human basophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006830(CHEMBL3236948)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CRTH2 receptor-mediated chemotaxis in human basophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006830(CHEMBL3236948)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human CRTH2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401108(CHEMBL2205148)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006891(CHEMBL3236958)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401097(CHEMBL2204469)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194988(4-(3-chloro-4-fluorophenylamino)-6-((1,5-dimethyl-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Tpl2 kinase by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194998(4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1H-i...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Tpl2 kinase by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401097(CHEMBL2204469)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006818(CHEMBL3236951)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006823(CHEMBL3236950)
Affinity DataIC50: 3nMT: 2°CAssay Description:Antagonist activity at CRTh2 in human peripheral blood assessed as inhibition of PGD2-induced eosinophil shape change at room temperature by flow cyt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006894(CHEMBL3236955)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006899(CHEMBL3237239)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401120(CHEMBL2204470)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006827(CHEMBL3236949)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006830(CHEMBL3236948)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse CRTH2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006880(CHEMBL3236960)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006896(CHEMBL3237242)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201921(2-Biphenyl-4-yl-6-fluoro-3-hydroxy-quinoline-4-car...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401118(CHEMBL2204472)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006870(CHEMBL3237230)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006893(CHEMBL3236956)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201923(3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-quinoline-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201945(6-fluoro-3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401117(CHEMBL2204473)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006830(CHEMBL3236948)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006865(CHEMBL3237233)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006866(CHEMBL3237232)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006895(CHEMBL3237243)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201905(3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-carboxyli...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201919(6-fluoro-3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-qu...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201925(2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARB...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401111(CHEMBL2204479)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401097(CHEMBL2204469)
Affinity DataIC50: 7nMAssay Description:Inhibition of mouse CRTH2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006892(CHEMBL3236957)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006830(CHEMBL3236948)
Affinity DataIC50: 8nMT: 2°CAssay Description:Antagonist activity at CRTh2 in human peripheral blood assessed as inhibition of PGD2-induced eosinophil shape change at room temperature by flow cyt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006890(CHEMBL3236959)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006897(CHEMBL3237241)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006898(CHEMBL3237240)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006918(CHEMBL3236945)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human recombinant CRTh2 expressed in CHO-K1 cells by cAMP TR FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401122(CHEMBL2205146)
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in CHO-K1 cells after 30 min by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50201949(2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic a...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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