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TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114564(CHEMBL3608378)
Affinity DataIC50: 80nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114565(CHEMBL3608855)
Affinity DataIC50: 180nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114427(CHEMBL3608361)
Affinity DataIC50: 220nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114425(CHEMBL3608359)
Affinity DataIC50: 240nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114426(CHEMBL3608360)
Affinity DataIC50: 290nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114428(Myrtucommulone H)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114563(CHEMBL3608377)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114430(CHEMBL3608363)
Affinity DataIC50: 390nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019157(CHEMBL3289097)
Affinity DataIC50: 400nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019160(CHEMBL3289100)
Affinity DataIC50: 400nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50: 430nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114425(CHEMBL3608359)
Affinity DataIC50: 460nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114422(CHEMBL3608860)
Affinity DataIC50: 480nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114551(CHEMBL3608367)
Affinity DataIC50: 490nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114560(CHEMBL3608374)
Affinity DataIC50: 570nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114567(Myrtucommulone F)
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114552(CHEMBL3608368)
Affinity DataIC50: 610nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114431(CHEMBL3608364)
Affinity DataIC50: 640nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114421(CHEMBL3608859)
Affinity DataIC50: 650nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114427(CHEMBL3608361)
Affinity DataIC50: 660nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114554(CHEMBL3608370)
Affinity DataIC50: 680nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114566(CHEMBL3608856)
Affinity DataIC50: 680nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50: 690nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114419(CHEMBL3608857)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114562(CHEMBL3608376)
Affinity DataIC50: 810nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114419(CHEMBL3608857)
Affinity DataIC50: 810nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114429(CHEMBL3608362)
Affinity DataIC50: 820nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019154(CHEMBL3289107)
Affinity DataIC50: 900nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50303448(Beta-elemonic acid | CHEMBL566929)
Affinity DataIC50: 900nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114426(CHEMBL3608360)
Affinity DataIC50: 970nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114551(CHEMBL3608367)
Affinity DataIC50: 980nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019162(CHEMBL3289103)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019156(CHEMBL3289096 | CHEBI:10274)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114556(CHEMBL3608372)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50019158(CHEMBL3289098)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114421(CHEMBL3608859)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114428(Myrtucommulone H)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114552(CHEMBL3608368)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114565(CHEMBL3608855)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114419(CHEMBL3608857)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114564(CHEMBL3608378)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114430(CHEMBL3608363)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114549(CHEMBL3608365)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114550(CHEMBL3608366)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114564(CHEMBL3608378)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114422(CHEMBL3608860)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-LO in ionomycin-stimulated human PMNL using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114431(CHEMBL3608364)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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