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TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033531(CHEMBL333410 | N-[1-(2-Hydroxy-2-phenyl-ethyl)-3-m...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110268(CHEMBL2369895 | CSNLSTCVLGKLSQELc[DKLQK]YPRTNTGSGT...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50024170(CHEMBL2369912)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110272(CHEMBL2369907 | CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGT...)
Affinity DataKi:  0.0510nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033533(CHEMBL121403 | N-[(3R,4R)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110265(CHEMBL2369886 | CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGT...)
Affinity DataKi:  0.0690nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110275(CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide | CHEMBL2...)
Affinity DataKi:  0.0690nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033534(CHEMBL338510 | N-[(3S,4S)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85393(14β-(p-chlorocinnamoylamino)-7,8-dihydrocodei...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033536(CHEMBL121494 | N-[(3R,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.130nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033530(CHEMBL121211 | N-[(3S,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.150nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033530(CHEMBL121211 | N-[(3S,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.150nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85790(Salmon MCH)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85789([Phe13,Tyr19]MCH)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85396(CACO)
Affinity DataKi:  0.460nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110273(CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide | CHEMBL...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid receptor delta 1(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85393(14β-(p-chlorocinnamoylamino)-7,8-dihydrocodei...)
Affinity DataKi:  0.75nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMelanin-concentrating hormone receptor 2(Human)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85789([Phe13,Tyr19]MCH)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.840nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (V84L), using [3H]CGS-21680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85393(14β-(p-chlorocinnamoylamino)-7,8-dihydrocodei...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85394(N-CPM-CACO)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85395(MC-CAM)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMelanin-concentrating hormone receptor 2(Human)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85788(MCH | hMCH)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033537(CHEMBL121060 | N-[(3S,4R)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  2.89nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036127(CHEMBL11391 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human HLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM202643(US9242957, 7)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM202644(US9242957, 8)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
TargetIsoform 1 of Calcitonin receptor (1)(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110267(CGNLSTCBLGTYTQDFNKFHZYPQTAIGVGAP-amide | CHEMBL236...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033532(CHEMBL435380 | N-[(3S,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  5.85nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.90nMAssay Description:Agonist activity at delta opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50328814((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataKi:  7nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli using L-arginine as substrate assessed as formation of nitric oxide measured up to 6...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50207816(CHEMBL273094 | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50446250(CHEMBL3109188 | US9732037, Compound 9)
Affinity DataKi:  9.70nMAssay Description:Inhibition of rat recombinant nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex mea...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85394(N-CPM-CACO)
Affinity DataKi:  9.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM50446250(CHEMBL3109188 | US9732037, Compound 9)
Affinity DataKi:  10nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM196648(US9212144, 3 | US9242957, 65)
Affinity DataKi:  11nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOpioid receptor delta 1(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85395(MC-CAM)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50023383(CHEMBL3325611)
Affinity DataKi:  13nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM202651(US9242957, QJ-II-194)
Affinity DataKi:  13.2nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetKappa-type opioid receptor(Bovine)
University of Rochester

Curated by PDSP Ki Database
LigandPNGBDBM85395(MC-CAM)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50023384(CHEMBL3325610 | US9242957, QJ-II-203)
Affinity DataKi:  14.7nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50023384(CHEMBL3325610 | US9242957, QJ-II-203)
Affinity DataKi:  15nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  16nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails US Patent

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