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TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100416(1N-methyl-4-(2-amino-6-methylamino-9H-9-purinyl)-2...)
Affinity DataEC50:  2.55E+4nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100423((1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[6-(3-iodo-benzyl...)
Affinity DataEC50:  6.80E+3nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100418((1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro...)
Affinity DataEC50:  5.25E+3nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100422((1R,2S,4S,5S)-4-(6-Cyclopentylamino-purin-9-yl)-1-...)
Affinity DataEC50:  2.89E+3nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, at human A1 adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  3.03E+5nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100417((1R,2S,4S,5S)-4-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataEC50:  2.28E+3nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, at human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50004566(CHEMBL268431 | 9-chloro-2-(furan-2-yl)-[1,2,4]tria...)
Affinity DataIC50: 3.30nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053927(7-Methyl-2-phenyl-4-((E)-styryl)-1,4-dihydro-quino...)
Affinity DataIC50: 4.77nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053927(7-Methyl-2-phenyl-4-((E)-styryl)-1,4-dihydro-quino...)
Affinity DataIC50: 5.93nMAssay Description:Binding affinity for A1 receptors from rat cerebral cortex membranes using [3H]-(R(-PIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50373326(CHEMBL444278)
Affinity DataIC50: 8.40nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50004566(CHEMBL268431 | 9-chloro-2-(furan-2-yl)-[1,2,4]tria...)
Affinity DataIC50: 21nMAssay Description:Binding affinity for Adenosine A1 receptor from rat cerebral cortex membranes using [3H](R)-PIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50134963(Phosphoric acid mono-[(1R,5S)-4-(2-bromo-6-methyla...)
Affinity DataIC50: 37nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409764(CHEMBL2112867)
Affinity DataIC50: 49nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409757(CHEMBL2112864)
Affinity DataIC50: 52nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50009531(CHEMBL2112337 | 2-[6-Amino-2-(2-phenyl-propylamino...)
Affinity DataIC50: 68nMAssay Description:Binding affinity against Adenosine A2A receptor in rat striatal membranes b displacement of [3H]-CGS- 21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50134966(Phosphoric acid mono-[(1R,5S)-4-(6-amino-2-iodo-pu...)
Affinity DataIC50: 87nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053924(CHEMBL89093 | MRS1067 | 3,6-Dichloro-2-(2-isopropo...)
Affinity DataIC50: 100nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409761(CHEMBL2112863)
Affinity DataIC50: 157nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50084018(2-Phenylacetylamino-4,7-dihydro-5H-thieno[2,3-c]py...)
Affinity DataIC50: 186nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409762(CHEMBL2112865)
Affinity DataIC50: 221nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50084019(6,7-Dimethoxy-3-[4-(4-methoxy-phenyl)-thiazol-2-yl...)
Affinity DataIC50: 255nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409759(CHEMBL2112868)
Affinity DataIC50: 356nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409760(CHEMBL2112861)
Affinity DataIC50: 367nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50134967(Phosphoric acid mono-[(1R,5S)-4-(6-methylamino-2-m...)
Affinity DataIC50: 377nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50084017({[(2-Benzoylamino-5-bromo-phenyl)-phenyl-methyl]-a...)
Affinity DataIC50: 407nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding stimulated by 5 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409758(CHEMBL2112869)
Affinity DataIC50: 452nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50023498(2-(5-Bromo-furan-2-yl)-9-chloro-[1,2,4]triazolo[1,...)
Affinity DataIC50: 531nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50009531(CHEMBL2112337 | 2-[6-Amino-2-(2-phenyl-propylamino...)
Affinity DataIC50: 980nMAssay Description:Binding affinity against Adenosine A1 receptor in rat brain membranes by displacement of [3H]PIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50023498(2-(5-Bromo-furan-2-yl)-9-chloro-[1,2,4]triazolo[1,...)
Affinity DataIC50: 1.57E+3nMAssay Description:Binding affinity for Adenosine A1 receptor from rat cerebral cortex membranes using [3H](R)-PIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409756(CHEMBL2112866)
Affinity DataIC50: 1.87E+3nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50409763(CHEMBL2112007)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonistic activity against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053927(7-Methyl-2-phenyl-4-((E)-styryl)-1,4-dihydro-quino...)
Affinity DataKi:  0.110nMAssay Description:In vitro binding affinity at human Adenosine A3 receptor from HEK293 cells by [125I]AB-MECA displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM21221(2-Cl-IB-MECA | CHEMBL431733 | C-IBzA-MU | 2-chloro...)
Affinity DataKi:  0.330nMAssay Description:Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50453675(CHEMBL2113400)
Affinity DataKi:  0.330nMAssay Description:Binding affinity against adenosine A3 receptor from rat brain.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50369386(CHEMBL608327)
Affinity DataKi:  0.330nMAssay Description:Binding affinity against rat adenosine A3 receptor expressed in CHO cells using [125I]-.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM21221(2-Cl-IB-MECA | CHEMBL431733 | C-IBzA-MU | 2-chloro...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]AB-MECA from adenosine A3 receptor from HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]PIA from adenosine A1 receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053924(CHEMBL89093 | MRS1067 | 3,6-Dichloro-2-(2-isopropo...)
Affinity DataKi:  0.560nMAssay Description:In vitro binding affinity at human Adenosine A3 receptor from HEK293 cells by [125I]AB-MECA displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  0.590nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  0.590nMAssay Description:Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataKi:  0.600nMAssay Description:Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  0.650nMAssay Description:In vitro binding affinity at human Adenosine A3 receptor from HEK293 cells by [125I]AB-MECA displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  0.650nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50373326(CHEMBL444278)
Affinity DataKi:  0.780nMAssay Description:Inhibition of [3H]5 binding to P2Y purinoceptor 1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50367265(CHEMBL603401 | BDBM50396917 | CHEMBL1512545)
Affinity DataKi:  0.850nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50453539(CHEMBL2113613)
Affinity DataKi:  0.880nMAssay Description:Binding affinity for recombinant rat A3-adenosine receptor by the displacement of specific [125I]APNEA or [125I]-N6-(4-amino-3-iodobenzyl)-adenosine-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368449(CHEMBL610435)
Affinity DataKi: <1nMAssay Description:Affinity for adenosine A2 receptor at rat striatal membrane using 5 nM [3H]CGS-21680More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataKi:  1.10nMAssay Description:Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50453546(CHEMBL2113565)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for recombinant rat A3-adenosine receptor by the displacement of specific [125I]APNEA or [125I]-N6-(4-amino-3-iodobenzyl)-adenosine-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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