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TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50495099(CHEMBL3105705)
Affinity DataEC50:  110nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50495100(CHEMBL3105238)
Affinity DataEC50:  94nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataEC50:  32nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  446nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525145(CHEMBL4454307)
Affinity DataKd:  3.50E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  1.38E+4nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525146(CHEMBL4462272)
Affinity DataKd:  1.73E+4nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525147(CHEMBL4554653)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525148(CHEMBL1978769)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525149(CHEMBL4457006)
Affinity DataKd:  9.36E+4nMAssay Description:Binding affinity to human TNFalpha by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Mouse)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525150(CHEMBL4469489)
Affinity DataKd:  2.84E+5nMAssay Description:Binding affinity to mouse N-terminal His6-Trx-tagged RANKL ectodomain (157 to 316 residues) expressed in Escherichia coli BL21 (DE3) by isothermal ti...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525151(CHEMBL4470163)
Affinity DataKd:  7.30E+3nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525149(CHEMBL4457006)
Affinity DataKd:  614nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525152(CHEMBL4514088)
Affinity DataKd:  6.30E+3nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525150(CHEMBL4469489)
Affinity DataKd:  2.84E+5nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Human)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525153(CHEMBL4560856)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor ligand superfamily member 11(Mouse)
Shanghai Jiaotong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50525146(CHEMBL4462272)
Affinity DataKd:  1.73E+4nMAssay Description:Binding affinity to mouse N-terminal His6-Trx-tagged RANKL ectodomain (157 to 316 residues) expressed in Escherichia coli BL21 (DE3) by isothermal ti...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50021357(CHEMBL3288586)
Affinity DataEC50:  213nMAssay Description:Inhibition of p-glycoprotein in human MDA435/LCC6MDR cells assessed as concentration required to reduce taxol IC50 by half after 5 days by MTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50021358(CHEMBL3288595)
Affinity DataEC50:  211nMAssay Description:Inhibition of p-glycoprotein in human MDA435/LCC6MDR cells assessed as concentration required to reduce taxol IC50 by half after 5 days by MTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091264(CHEMBL3582155)
Affinity DataEC50:  159nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091138(CHEMBL3582168)
Affinity DataEC50:  108nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091271(CHEMBL3582148)
Affinity DataEC50:  157nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091112(CHEMBL3582167)
Affinity DataEC50:  173nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091265(CHEMBL3582149)
Affinity DataEC50:  127nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  385nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091138(CHEMBL3582168)
Affinity DataEC50:  107nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091112(CHEMBL3582167)
Affinity DataEC50:  208nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091271(CHEMBL3582148)
Affinity DataEC50:  167nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091265(CHEMBL3582149)
Affinity DataEC50:  123nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091087(CHEMBL3582156)
Affinity DataEC50:  214nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091264(CHEMBL3582155)
Affinity DataEC50:  181nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataEC50:  32nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataEC50:  43nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091264(CHEMBL3582155)
Affinity DataEC50:  193nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  503nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091138(CHEMBL3582168)
Affinity DataEC50:  140nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091265(CHEMBL3582149)
Affinity DataEC50:  195nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091112(CHEMBL3582167)
Affinity DataEC50:  171nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091271(CHEMBL3582148)
Affinity DataEC50:  123nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091161(CHEMBL3582170)
Affinity DataEC50:  225nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091146(CHEMBL3582169)
Affinity DataEC50:  280nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091112(CHEMBL3582167)
Affinity DataEC50:  147nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091138(CHEMBL3582168)
Affinity DataEC50:  102nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091264(CHEMBL3582155)
Affinity DataEC50:  139nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091271(CHEMBL3582148)
Affinity DataEC50:  160nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50091265(CHEMBL3582149)
Affinity DataEC50:  130nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  446nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  245nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50109277(CHEMBL3601686)
Affinity DataEC50:  423nMAssay Description:Modulation of P-gp in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50109277(CHEMBL3601686)
Affinity DataEC50:  423nMAssay Description:Modulation of P-gp in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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