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LigandPNGBDBM50331161(4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-i...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331251((R)-4-(benzyloxy)-1-(1-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331242(2-(4-chloro-2-fluorophenyl)-5-(1-(2-(pyrrolidin-1-...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331245(4-(benzyloxy)-1-(1-(2-(dimethylamino)ethyl)-1H-ind...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331234((S)-4-(benzyloxy)-1-(1-(2-(3-hydroxypyrrolidin-1-y...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331236(2-(4-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331239(2-(4-fluorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331248((S)-4-(benzyloxy)-1-(1-(2-(3-methoxypyrrolidin-1-y...)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331244(2-phenyl-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazo...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331252((R)-4-(benzyloxy)-1-(1-(2-(2-(methoxymethyl)pyrrol...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331249((S)-4-(benzyloxy)-1-(1-(pyrrolidin-2-ylmethyl)-1H-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331246(4-(benzyloxy)-1-(1-(3-(dimethylamino)propyl)-1H-in...)
Affinity DataKi:  12.6nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331243(2-(2,4-dichlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)et...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331255(1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethy...)
Affinity DataKi:  17.3nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331238(4-(benzyloxy)-1-(1-((4,5-dihydro-1H-imidazol-2-yl)...)
Affinity DataKi:  22.6nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331256(4-(benzyloxy)-1-(1-(2-(piperazin-1-yl)ethyl)-1H-in...)
Affinity DataKi:  24.3nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331235(2-(2-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331253(4-(benzyloxy)-1-(1-((1-methyl-4,5-dihydro-1H-imida...)
Affinity DataKi:  30.4nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331250(4-(benzyloxy)-1-(1-(((4R)-4-hydroxypyrrolidin-2-yl...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331247(4-(benzyloxy)-1-(1-(3-(dimethylamino)-2-hydroxypro...)
Affinity DataKi:  37.7nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331241(2-(3-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331254(4-(benzyloxy)-1-(1-(2-morpholinoethyl)-1H-indazol-...)
Affinity DataKi:  43.4nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331240(2-(4-chloro-2-methoxyphenyl)-5-(1-(2-(pyrrolidin-1...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331237(2-(pyridin-2-yl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331233(2-(pyrimidin-2-yl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  1.68E+3nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331232(4-(benzyloxy)-1-(1-butyl-1H-indazol-5-yl)pyridin-2...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353115(CHEMBL1829127)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353110(CHEMBL1829122)
Affinity DataIC50:  0.0730nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353113(CHEMBL1829125)
Affinity DataIC50:  0.0840nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353114(CHEMBL1829126)
Affinity DataIC50:  0.0910nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353111(CHEMBL1829123)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353097(CHEMBL1829132)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353116(CHEMBL1829128)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353098(CHEMBL1829133)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353103(CHEMBL1829139)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353102(CHEMBL1829138)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353105(CHEMBL1829117)
Affinity DataIC50:  1.06nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353099(CHEMBL1829134)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353101(CHEMBL1829137)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50345911(CHEMBL1783852 | CHEMBL1789669 | N-(diaminomethylen...)
Affinity DataIC50:  1.82nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331161(4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-i...)
Affinity DataIC50:  14nMAssay Description:Antagonistic activity at MCH-1 receptor expressed in CHO-K1 cell assessed as inhibition of MCH-induced calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50331236(2-(4-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Affinity DataIC50:  23nMAssay Description:Antagonistic activity at MCH-1 receptor expressed in CHO-K1 cell assessed as inhibition of MCH-induced calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  30.7nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353095(CHEMBL1829130)
Affinity DataIC50:  49.3nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420296(Advanced SARS-CoV-2 Inhibitor 11a | MPI10 | acs.jm...)
Affinity DataIC50:  53nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353118(CHEMBL1829136)
Affinity DataIC50:  55.7nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353107(CHEMBL1829119)
Affinity DataIC50:  93.5nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353112(CHEMBL1829124)
Affinity DataIC50:  125nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353117(CHEMBL1829129)
Affinity DataIC50:  139nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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