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Report error Found 100 with Last Name = 'joffe' and Initial = 'm'
LigandPNGBDBM27634(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311010(N-(4-{2-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27633(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311001(2-methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311011(N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)ph...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27628(5-bromo-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27637(N-{3-[(1S)-1-[(5-bromopyridin-3-yl)amino]ethyl]phe...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27627(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311012(N-(4-(2-(4-(4-hydroxypiperidin-1-yl)phenylamino)py...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311002(N-(4-(2-(3-(pyrrolidin-1-ylmethyl)phenylamino)pyri...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311022(N-(cyanomethyl)-4-(5-methyl-2-(4-morpholinophenyla...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311004(N-(4-(2-(3-(morpholinomethyl)phenylamino)pyrimidin...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27631(3-chloro-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27632(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311019(N-(cyanomethyl)-2-methoxy-4-(2-(4-morpholinophenyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311006(N-(4-(2-(4-(morpholinomethyl)phenylamino)pyrimidin...)
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27630(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311016(2-cyano-N-(4-(2-(4-morpholinophenylamino)pyrimidin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311003(N-(4-(2-(4-(piperidin-1-ylmethyl)phenylamino)pyrim...)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged JAK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27639(N-{3-[(1S)-1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazi...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311005(N-(4-(2-(3-((4-hydroxypiperidin-1-yl)methyl)phenyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311008(N-(4-(2-(3-((4-methylpiperazin-1-yl)methyl)phenyla...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27626(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311007(N-(4-(2-(4-((4-hydroxypiperidin-1-yl)methyl)phenyl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311000(4-(4-amino-3-methoxyphenyl)-N-(4-morpholinophenyl)...)
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311009(N-(4-(2-(4-((4-methylpiperazin-1-yl)methyl)phenyla...)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27619(N-[3-(1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazin-2-y...)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311019(N-(cyanomethyl)-2-methoxy-4-(2-(4-morpholinophenyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50310999(4-(1H-indol-5-yl)-N-(4-morpholinophenyl)pyrimidin-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 33nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27629(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27625(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311032(N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311031(N-(cyanomethyl)-4-(2-(4-((4-ethylpiperazin-1-yl)me...)
Affinity DataIC50: 47nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311030(N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomo...)
Affinity DataIC50: 52nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311001(2-methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311018(N-(cyanomethyl)-2-methyl-4-(2-(4-morpholinophenyla...)
Affinity DataIC50: 65nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311016(2-cyano-N-(4-(2-(4-morpholinophenylamino)pyrimidin...)
Affinity DataIC50: 66nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50310998(N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)ph...)
Affinity DataIC50: 67nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311029(N-(cyanomethyl)-4-(2-(4-thiomorpholinophenylamino)...)
Affinity DataIC50: 69nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50310997(4-(4-((2-methyl-1H-imidazol-1-yl)methyl)phenyl)-N-...)
Affinity DataIC50: 81nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50310996(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benze...)
Affinity DataIC50: 83nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311022(N-(cyanomethyl)-4-(5-methyl-2-(4-morpholinophenyla...)
Affinity DataIC50: 85nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50310995(2,6-dimethyl-4-(2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50: 88nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311002(N-(4-(2-(3-(pyrrolidin-1-ylmethyl)phenylamino)pyri...)
Affinity DataIC50: 110nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311028(N-(cyanomethyl)-4-(2-(3-morpholinophenylamino)pyri...)
Affinity DataIC50: 113nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311027(N-(cyanomethyl)-4-(2-(3-fluoro-4-morpholinophenyla...)
Affinity DataIC50: 116nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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