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TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304044([({[(2R,3R,4S,5S,6S)-6-[(2-{[(tert-butoxy)carbonyl...)
Affinity DataEC50:  951nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304042(Diphosphoric Acid 1''-alpha-D-[1'']Fructofuranosyl...)
Affinity DataEC50:  323nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304033(Diphosphoric Acid 1''-alpha-D-[1''](3''-Fluoro-3''...)
Affinity DataEC50:  361nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258291(9-[5'-Deoxy-5'-[(hydroxyphosphoroxy)phosphinyl]-be...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209663(MRS-2670 | diphosphoric acid 1-alpha-D-glucopyrano...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304043({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyr...)
Affinity DataEC50:  1.88E+3nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304037({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyr...)
Affinity DataEC50:  496nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304040(Diphosphoric Acid 1''-alpha-D-[5'']Ribofuranosyl E...)
Affinity DataEC50:  238nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304032(URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GL...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304036(Diphosphoric acid 1''-alpha-D-[1''](glucuronic aci...)
Affinity DataEC50:  2.59E+3nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institutes of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  10.3nMAssay Description:Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304030(Diphosphoric Acid 1''-beta-D-[1'']Glucopyranosyl E...)
Affinity DataEC50:  588nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50197974(udp-N-acetyl-glucosamine)
Affinity DataEC50:  4.38E+3nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50197974(udp-N-acetyl-glucosamine)
Affinity DataEC50:  4.38E+3nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institutes of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50308552((1'S,2'R,3'S,4'R,5'S)-4-(6-Amino-2-chloro-9H-purin...)
Affinity DataEC50:  722nMAssay Description:Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50177308((2S,3S,4R,5R)-5-[2-dimethylamino-6-(3-iodo-benzyla...)
Affinity DataEC50: >1.00E+4nMAssay Description:Potency against human Adenosine A2B receptor transfected in CHO cells by the stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209659(uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen di...)
Affinity DataEC50:  261nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304034(URIDINE-5'-DIPHOSPHATE-4-DEOXY-4-FLUORO-ALPHA-D-GA...)
Affinity DataEC50:  567nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304041(Diphosphoric Acid 1''-alpha-D-[5'']Arabinofuranosy...)
Affinity DataEC50:  460nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50179185(DEOXYURIDINE-5'-DIPHOSPHATE | 2'-Deoxyuridine-5'-d...)
Affinity DataEC50:  1.72E+3nMAssay Description:Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258288(9-[5'-Deoxy-5'-[(hydroxypyrophosphoroxy)phosphinyl...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304035(Diphosphoric Acid 1''-alpha-D-[1''](6''-Fluoro-6''...)
Affinity DataEC50:  905nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304038(Diphosphoric Acid 1''-alpha-D-[6'']Glucopyranosyl ...)
Affinity DataEC50:  373nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209669(MRS-2670 | diphosphoric acid 1-alpha-D-glucopyrano...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209666(URIDINE-5'-DIPHOSPHATE-MANNOSE | CHEMBL227711)
Affinity DataEC50:  910nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304031(Diphosphoric Acid 1''-alpha-D-[1'']Fucopyranosyl E...)
Affinity DataEC50:  562nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50177309((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H...)
Affinity DataEC50: >1.00E+4nMAssay Description:Potency against human Adenosine A2B receptor transfected in CHO cells by the stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM2(CHEMBL14249 | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataEC50:  85nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258427(uridine5'-methylene-phosphonate | CHEMBL522015)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50209659(uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen di...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cellsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50304039(Diphosphoric Acid 1''-alpha-D-[6'']Mannopyranosyl ...)
Affinity DataEC50:  658nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50410570(CHEMBL2113161)
Affinity DataEC50:  230nMAssay Description:Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258291(9-[5'-Deoxy-5'-[(hydroxyphosphoroxy)phosphinyl]-be...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258289(9-[5'-Deoxy-5'-[(hydroxypyrophosphoroxy)phosphinyl...)
Affinity DataEC50:  8.60E+3nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  86nMAssay Description:Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209668(Galactose-Uridine-5'-Diphosphate | CHEMBL439009)
Affinity DataEC50:  670nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209661([({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydrop...)
Affinity DataEC50:  880nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 14(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50209665(uridine 5'-[3-(alpha-D-glucopyranuronosyl) dihydro...)
Affinity DataEC50:  370nMAssay Description:Agonist activity at human P2Y14 receptor expressed in human COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50258290(1-[5,6-Dideoxy-6-[(hydroxypyrophosphoroxy)phosphon...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50177307((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H...)
Affinity DataEC50: >1.00E+4nMAssay Description:Potency against human Adenosine A2B receptor transfected in CHO cells by the stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institutes of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50308552((1'S,2'R,3'S,4'R,5'S)-4-(6-Amino-2-chloro-9H-purin...)
Affinity DataEC50:  1.89nMAssay Description:Agonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50264213((1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(3-iodobenzyl...)
Affinity DataIC50: 29.8nMAssay Description:Antagonist activity at NECA-stimulated human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230072((S)-tert-butyl 4-(3-(4-(isoquinolin-5-ylsulfonylox...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced K(+) effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institutes of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50215406((1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-stimulated PLC activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institutes of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50215406((1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-induced inositol phosphate formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230061((S)-4-(3-(4-benzoylpiperazin-1-yl)-2-(benzyloxycar...)
Affinity DataIC50: 117nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50: 175nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230056((S)-4-(3-(4-benzoylpiperazin-1-yl)-2-(benzyloxycar...)
Affinity DataIC50: 219nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230067(4-((S)-3-((R)-4-benzoyl-3-methylpiperazin-1-yl)-2-...)
Affinity DataIC50: 256nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230055(4-((S)-3-((S)-4-benzoyl-3-methylpiperazin-1-yl)-2-...)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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