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TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC7 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 5(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC6 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Mouse)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
TargetNeuroendocrine convertase 2(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  0.360nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC2 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50170682((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50156173((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038881(CHEMBL294803 | Y-29794 | [2-(8-Dimethylamino-octyl...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC1 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuroendocrine convertase 1(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC3 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50079424((S)-3-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-2-(4,6-dim...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mouse)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316840((R)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)i...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mouse)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316839((S)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)-...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  3.60nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC4 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50049189(3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50079424((S)-3-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-2-(4,6-dim...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I]ET-3 from human ET-B receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50282396((S)-1-(4-Dimethylamino-3-methyl-benzyl)-5-diphenyl...)
Affinity DataKi:  12nMAssay Description:Inhibition of human AT1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316819((S)-1-(4-(4-chlorobenzylamino)-4-oxobutanoyl)pyrro...)
Affinity DataKi:  12nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168997(4-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)
Affinity DataKi:  19nMAssay Description:Binding affinity against alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant FAPalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant FAPalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mouse)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316836((9H-fluoren-9-yl)methyl(S)-1-((S)-2-cyanopyrrolidi...)
Affinity DataKi:  33nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316835((S)-benzyl 2-(thiazolidine-3-carbonyl)pyrrolidine-...)
Affinity DataKi:  39nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)
Affinity DataKi:  40nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Human)
Chuv-Unil

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  126nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  135nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  211nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Human)
Chuv-Unil

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  377nMAssay Description:Inhibition of recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  550nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  670nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168999((2R,3R,4R,5R)-5-(Benzylamino-methyl)-pyrrolidine-2...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168991((2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-...)
Affinity DataKi:  1.35E+3nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316834((S)-2-(1-Oxo-1lambda*4*-thiazolidine-3-carbonyl)-p...)
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514581(CHEMBL1885579)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316820((S)-benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168998((2R,3R,4S)-2-((R)-Indan-1-ylaminomethyl)-pyrrolidi...)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316825(2-(2,3-dihydro-1H-inden-2-yl)-1-((R)-4-((R)-4-(dim...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316833((S)-benzyl 2-(oxazolidine-3-carbonyl)pyrrolidine-1...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316828((S)-tert-butyl 3-methyl-1-(thiazolidin-3-yl)-1-thi...)
Affinity DataKi:  5.54E+3nMAssay Description:Inhibition of human placenta POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168993((2R,3R,4S)-2-(Benzylamino-methyl)-pyrrolidine-3,4-...)
Affinity DataKi:  7.40E+3nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Human)
Chuv-Unil

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  9.50E+3nMAssay Description:Binding affinity towards alpha-Mannosidase isolated from AlmondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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