BindingDB PrimarySearch_ki

Found 535 with Last Name = 'karlberg' and Initial = 't'

Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50232346(CHEMBL4101890)

IC50: 0.600nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50232346(CHEMBL4101890)

IC50: 0.600nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 1.10nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 1.40nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)

IC50: 3.20nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)

IC50: 3.20nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 autophosphorylation at ADP-ribosyltransferase domain by LC-MS/MS methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)

IC50: 3.30nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)

IC50: 3.40nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)

IC50: 4nMAssay Description:Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)

IC50: 4nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 4.10nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 4.20nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 5.20nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 5.25nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 10nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)

IC50: 11nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)

IC50: 11nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)

IC50: 11nMAssay Description:Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50007582(CHEMBL3238252)

IC50: 12nMAssay Description:Inhibition of recombinant human TNKS-1More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 12nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 12nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 15nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 15nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 16nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)

IC50: 17nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 17nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)

IC50: 18nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 18.9nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 27nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)

IC50: 28nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)

IC50: 33nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)

IC50: 34nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)

IC50: 35nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)

IC50: 40nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-2(Mus musculus)
Universit£ degli Studi di Perugia

Curated by ChEMBL

PNG

BDBM50007583(CHEBI:62882 | CHEMBL562310)

IC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)

IC50: 60nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)

IC50: 61nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 63nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Protein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 63nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 69nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)

IC50: 69.2nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 74nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 79nMAssay Description:Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...More data for this Ligand-Target Pair

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Protein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)

IC50: 79nMAssay Description:Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 95nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

IC50: 95.5nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50232346(CHEMBL4101890)

IC50: 100nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL

PNG

BDBM50232346(CHEMBL4101890)

IC50: 100nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 107nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health & Science University

Curated by ChEMBL

PNG

BDBM50145156(CHEMBL3764816)

IC50: 108nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 535 total ) | Next | Last >>

Filter my 535 hits

Targets 12▿
- Poly [ADP-ribose] polymerase 1 128
- Protein mono-ADP-ribosyltransferase PARP14 103
- Protein mono-ADP-ribosyltransferase PARP10 103
- Poly [ADP-ribose] polymerase tankyrase-1 42
- Protein mono-ADP-ribosyltransferase PARP15 40
- Poly [ADP-ribose] polymerase 2 26
- Poly [ADP-ribose] polymerase tankyrase-2 25
- Protein mono-ADP-ribosyltransferase PARP3 [R100H] 23
- Protein mono-ADP-ribosyltransferase PARP3 16
- Protein mono-ADP-ribosyltransferase PARP4 13
- Protein mono-ADP-ribosyltransferase PARP12 11
- Protein mono-ADP-ribosyltransferase PARP16 5
- ...
Publications 10▿
- J Med Chem 60: 1262-1271 (2017) 189
- Eur J Med Chem 95: 546-51 (2015) 121
- Bioorg Med Chem Lett 28: 2050-2054 (2018) 87
- Bioorg Med Chem Lett 27: 2907-2911 (2017) 70
- J Med Chem 56: 9556-68 (2014) 32
- J Med Chem 52: 3108-11 (2009) 10
- ACS Chem Biol 8: 1698-703 (2013) 9
- J Med Chem 57: 2807-12 (2014) 8
- J Med Chem 53: 5352-5 (2010) 7
- J Med Chem 55: 7706-18 (2012) 2
Institutions 6▿
- Health & Science University 189
- McDaniel College 157
- Karolinska Institutet 128
- Ume£ University 43
- Institutet 10
- Universit£ degli Studi di Perugia 8
Affinity: 0.60 to 1.0E+5 nM▿
- IC50 520
- Kd 15
- Affinity ≤ nM
Xtal structures: 27
Docked structures: 0
Catalog Cmpds: 35