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TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606428(CHEMBL5192377)
Affinity DataKd:  2.19E+3nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50423822(CHEMBL1830621)
Affinity DataKd: >1.00E+3nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530697(CHEMBL4465318)
Affinity DataKd:  214nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432701(CHEMBL2348201)
Affinity DataKd:  794nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606418(CHEMBL5187345)
Affinity DataKd:  66nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetP2Y purinoceptor 2(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50366480(ATP | ADENOSINE TRIPHOSPHATE)
Affinity DataEC50:  230nMAssay Description:Agonist activity at human P2Y2 transfected in human 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25746(cid_2685 | 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-meth...)
Affinity DataKd:  1.05E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432703(CHEMBL2348217)
Affinity DataKd: >1.00E+4nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027876(CHEMBL2348200)
Affinity DataKd:  2.88E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027884(CHEMBL2348204)
Affinity DataKd:  1.02E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50019443(LB-46 | 1-(1H-Indol-4-yloxy)-3-isopropylamino-prop...)
Affinity DataKd:  0.537nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50423822(CHEMBL1830621)
Affinity DataKd:  11nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027872(CHEMBL2348215)
Affinity DataKd:  95nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432707(LK-204-545 | LK-204545)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50064946(4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-hydro...)
Affinity DataKd:  91nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25764(ALPRENOLOL,(-) | CHEMBL266195 | ALPRENOLOL,(+) | A...)
Affinity DataKd:  178nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  81nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432702(CHEMBL2348211)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25748(ICI 89,406 | 3-(2-{[3-(2-cyanophenoxy)-2-hydroxypr...)
Affinity DataKd:  145nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027881(CHEMBL2348207)
Affinity DataKd:  1.38E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50474701(CHEMBL147830)
Affinity DataKd:  1.90nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50583648(CHEMBL5092175)
Affinity DataKd:  6.20nMAssay Description:Antagonist activity at N-terminal NLuc tagged human A3 adenosine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606411(CHEMBL5187728)
Affinity DataKd:  11nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetP2Y purinoceptor 14(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human P2Y14 expressed in rat CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50422942(CHEMBL414055)
Affinity DataKd:  158nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50423821(CHEMBL1830486)
Affinity DataKd:  79nMAssay Description:Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence corr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataKd:  1nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25768(ICI 118,551 | 1-[(7-methyl-2,3-dihydro-1H-inden-4-...)
Affinity DataKd:  240nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027871(CHEMBL2348216)
Affinity DataKd:  891nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027877(CHEMBL2348199)
Affinity DataKd:  1.20E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530685(CHEMBL4468416)
Affinity DataKd:  120nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50362867(CHEMBL1940403)
Affinity DataKd:  1.90nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530707(CHEMBL4584060)
Affinity DataKd:  288nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50583640(CHEMBL5075285)
Affinity DataKd:  135nMAssay Description:Binding affinity to NLuc human A3 adenosine receptor expressed in HEK293-A cells in presence of 1 uM MRS1220 by NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606400(CHEMBL5201153)
Affinity DataKd:  20nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50423829(CHEMBL1830485)
Affinity DataKd:  26nMAssay Description:Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence corr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530701(CHEMBL611991)
Affinity DataKd:  41nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606412(CHEMBL5207609)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataKd:  7.40nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027882(CHEMBL2348206)
Affinity DataKd:  115nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataKd:  162nMAssay Description:Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence corr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530686(CHEMBL4576998)
Affinity DataKd:  60nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50530708(CHEMBL4440708)
Affinity DataKd:  32nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50583646(CHEMBL5078671)
Affinity DataKd:  1.78E+3nMAssay Description:Binding affinity to N-terminal NLuc tagged rat A1 adenosine receptor expressed in Flp-In-CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetP2Y purinoceptor 14(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  74nMAssay Description:Agonist activity at human P2Y14 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50583644(CHEMBL5080679)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to NLuc human A1 adenosine receptor expressed in HEK293-A cells in presence of 1 uM SLV320 by NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKd:  5nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nottingham Biodiscovery Institute

Curated by ChEMBL
LigandPNGBDBM50606425(CHEMBL5208169)
Affinity DataKd:  724nMAssay Description:Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25764(ALPRENOLOL,(-) | CHEMBL266195 | ALPRENOLOL,(+) | A...)
Affinity DataKd:  0.295nMAssay Description:Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50423872(CHEMBL2024150)
Affinity DataKd:  3.40nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
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