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TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542836(CHEMBL4643863)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542850(CHEMBL4633774)
Affinity DataEC50:  162nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542856(CHEMBL4639709)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542835(CHEMBL4649711)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50578260(CHEMBL4858915)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T-ARRB2 cells assessed as stimulation of beta-arrestin 2 recruitment by multi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542849(CHEMBL4641831)
Affinity DataEC50:  160nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542842(CHEMBL4640794)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542844(CHEMBL4646391)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50543285(CHEMBL4637356)
Affinity DataKd:  48nMAssay Description:Binding affinity to human H2R expressed in human HEK293T cells incubated for 90 mins by flowcytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509508(CHEMBL4534768)
Affinity DataKd:  10nMAssay Description:Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50535850(CHEMBL3787766)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as induction of calcium mobilization by aequorin l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542835(CHEMBL4649711)
Affinity DataEC50:  51nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50159155(CHEMBL3786852)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413178(CHEMBL469749)
Affinity DataEC50:  55.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542842(CHEMBL4640794)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542849(CHEMBL4641831)
Affinity DataEC50:  148nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542834(CHEMBL4633593)
Affinity DataEC50:  182nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Friedrich-Alexander-Universitat Erlangen-Nurnberg

Curated by ChEMBL
LigandPNGBDBM50004656((2-Hydroxyethyl)trimethyl ammonium chloride carbam...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human muscarinic M3 receptor expressed in human HEK293T cells assessed as activation of G-protein signaling by measuring inositol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413176(CHEMBL513883)
Affinity DataEC50:  204nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86171(CAS_65895 | NSC_65895 | Arpromidine)
Affinity DataEC50:  9.77nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542841(CHEMBL4645738)
Affinity DataEC50:  148nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542850(CHEMBL4633774)
Affinity DataEC50:  51nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542856(CHEMBL4639709)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86745(UR-AK51)
Affinity DataEC50:  166nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50535857(CHEMBL4581256)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as induction of calcium mobilization by aequorin l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542842(CHEMBL4640794)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542857(CHEMBL4646230)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538313(CHEMBL4644612)
Affinity DataKd:  26nMAssay Description:Binding affinity to human muscarinic M1 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538312(CHEMBL4641726)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538314(CHEMBL4636899)
Affinity DataKd:  5.62nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542847(CHEMBL4637617)
Affinity DataEC50:  427nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50557935(CHEMBL4756833)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50528183(CHEMBL4540843)
Affinity DataEC50:  10.6nMAssay Description:Agonist activity at human neuropeptide Y Y4 receptor expressed in CHO-mtAEQ cells co-expressing Gqi5 by calcium aequorin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542851(CHEMBL4643458)
Affinity DataEC50:  230nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50246646(CHEMBL470495 | CHEMBL446342 | (R)-Nalpha-(2,2-diph...)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50578270(CHEMBL4852799)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T-ARRB2 cells assessed as stimulation of beta-arrestin 2 recruitment by multi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542842(CHEMBL4640794)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542851(CHEMBL4643458)
Affinity DataEC50:  234nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542837(CHEMBL4643522)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50543279(CHEMBL4641916)
Affinity DataKd:  74nMAssay Description:Binding affinity to human H2R expressed in human HEK293T cells incubated for 60 mins by automated cell imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  66.3nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413177(CHEMBL513039)
Affinity DataEC50:  398nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50543279(CHEMBL4641916)
Affinity DataKd:  87nMAssay Description:Binding affinity to human H2R expressed in human HEK293T cells incubated for 60 mins by imaging flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50557938(CHEMBL4744233)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50578272(CHEMBL4857577)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T-ARRB1 cells assessed as stimulation of beta-arrestin 1 recruitment by multi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50542846(CHEMBL4645462)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50578268(CHEMBL4856311)
Affinity DataEC50:  0.990nMAssay Description:Agonist activity at human neuropeptide Y Y4 receptor expressed in CHO-mtAEQ cells co-expressing Gqi5 by calcium aequorin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86736(UR-AK68)
Affinity DataKd: >1.00E+4nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50569847(CHEMBL4847300)
Affinity DataEC50:  6.30E+3nMAssay Description:Activation of human TRPML2-YFP expressed in HEK293 cells incubated for 10 mins by Fluo-4 dye calcium imaging based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMucolipin-3(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50569845(CHEMBL4851704)
Affinity DataEC50:  1.08E+4nMAssay Description:Activation of human TRPML3-YFP expressed in HEK293 cells incubated for 10 mins by Fluo-4 dye calcium imaging based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
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