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TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395965(CHEMBL2164910)
Affinity DataEC50:  28.2nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340312((2,3-dichlorophenyl)(1-((4,4-difluoropiperidin-1-y...)
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340311((3-fluoro-2-(trifluoromethyl)phenyl)(1-(morpholino...)
Affinity DataIC50: 0.700nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507325(CHEMBL4453586)
Affinity DataIC50: 1nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340313(1-((4,4-difluoropiperidin-1-yl)methyl)-N-(6-(trifl...)
Affinity DataIC50: 1.70nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507332(CHEMBL4475943)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GFP-fused PLD2 (unknown origin) expressed in HEK293 cells by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340315(3-((4,4-difluoropiperidin-1-yl)methyl)-N-((1-(hydr...)
Affinity DataIC50: 3nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PLD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340310((2,3-dichlorophenyl)(1-(morpholinomethyl)imidazo[1...)
Affinity DataIC50: 5nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM154517(ML299 (5))
Affinity DataIC50: 6nMAssay Description:Inhibition of PLD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322836(rac-N-(3-methyl-1-(piperidin-1-yl)pentan-3-yl)-N-(...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340316(3-cyclopropyl-N-(dicyclopropylmethyl)imidazo[1,5-a...)
Affinity DataIC50: 7nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 9nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340310((2,3-dichlorophenyl)(1-(morpholinomethyl)imidazo[1...)
Affinity DataIC50: 11nMAssay Description:Agonist activity at rat CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235250(CHEMBL4104525)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507325(CHEMBL4453586)
Affinity DataIC50: 12nMAssay Description:Inhibition of GFP-fused PLD2 (unknown origin) expressed in HEK293 cells by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322837(rac-N-(1-(4-fluoropiperidin-1-yl)-3-methylpentan-3...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507322(CHEMBL4448918)
Affinity DataIC50: 16nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507327(CHEMBL4514153)
Affinity DataIC50: 16nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395966(CHEMBL2164905)
Affinity DataIC50: 17.8nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322842(N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395966(CHEMBL2164905)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086214(CHEMBL3425744)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM154517(ML299 (5))
Affinity DataIC50: 20nMAssay Description:Inhibition of PLD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87120(N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PLD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507332(CHEMBL4475943)
Affinity DataIC50: 21nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50206160(Halopemide | CHEMBL245621 | Halopemide, 8 | cid_65...)
Affinity DataIC50: 21nMAssay Description:Inhibition of PLD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340317(3-cyclopropyl-N-neopentylimidazo[1,5-a]pyridine-1-...)
Affinity DataIC50: 21nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340318((R)-3-morpholino-N-(2,2,2-trifluoro-1-(pyridin-2-y...)
Affinity DataIC50: 21nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322838(rac-N-(1-(4,4-difluoropiperidin-1-yl)-3-methylpent...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235255(CHEMBL4085436)
Affinity DataIC50: 23nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507324(CHEMBL4570440)
Affinity DataIC50: 25nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50507321(CHEMBL4594070)
Affinity DataIC50: 26nMAssay Description:Inhibition of GFP-fused PLD2 (unknown origin) expressed in HEK293 cells by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235259(CHEMBL4105245)
Affinity DataIC50: 26nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395965(CHEMBL2164910)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235250(CHEMBL4104525)
Affinity DataIC50: 29nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235275(CHEMBL4062996)
Affinity DataIC50: 30nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide S receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322834(N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340319(N-((1-(hydroxymethyl)cyclopentyl)methyl)-3-morphol...)
Affinity DataIC50: 33nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50396000(CHEMBL2164906)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235253(CHEMBL4075394)
Affinity DataIC50: 33nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340321((R)-1-(4,4-difluoropiperidin-1-yl)-N-(3,3-dimethyl...)
Affinity DataIC50: 36nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395973(CHEMBL2164895)
Affinity DataIC50: 37.1nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50395973(CHEMBL2164895)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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