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TargetHistidine protein kinase SaeS(Staphylococcus aureus (strain NCTC 8325 / PS 47))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM76798(xanthoangelol B | (E)-1-[3-[(2E)-3,7-dimethyl-6-ox...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Staphylococcus aureus SaeS kinase domain after 15 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistidine protein kinase SaeS(Staphylococcus aureus (strain NCTC 8325 / PS 47))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50468034(CHEMBL4286992)
Affinity DataKd:  6.80E+3nMAssay Description:Binding affinity to Staphylococcus aureus SaeS kinase domain after 15 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437388(CHEMBL3037924)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437388(CHEMBL3037924)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437386(CHEMBL2408620)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437387(CHEMBL2408472)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437393(CHEMBL2408630)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437390(CHEMBL2408633)
Affinity DataIC50: 2nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437374(CHEMBL2408470)
Affinity DataIC50: 2nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437391(CHEMBL2408632)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437393(CHEMBL2408630)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437373(CHEMBL2408471)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437389(CHEMBL3037925)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437392(CHEMBL2408631)
Affinity DataIC50: 3nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437385(CHEMBL2408621)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437387(CHEMBL2408472)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437374(CHEMBL2408470)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437389(CHEMBL3037925)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437391(CHEMBL2408632)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437383(CHEMBL2408623)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437376(CHEMBL2408634)
Affinity DataIC50: 4nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437390(CHEMBL2408633)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437386(CHEMBL2408620)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437392(CHEMBL2408631)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437383(CHEMBL2408623)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437375(CHEMBL2408635)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437384(CHEMBL2408622)
Affinity DataIC50: 6nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437373(CHEMBL2408471)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437376(CHEMBL2408634)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437378(CHEMBL2408628)
Affinity DataIC50: 11nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437375(CHEMBL2408635)
Affinity DataIC50: 12nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437378(CHEMBL2408628)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437377(CHEMBL2408629)
Affinity DataIC50: 14nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437377(CHEMBL2408629)
Affinity DataIC50: 16nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485379(CHEMBL2059641)
Affinity DataIC50: 17.9nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50134709(CHEMBL3747057)
Affinity DataIC50: 30nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated with substrate for 10 mins followed by protein...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437380(CHEMBL2408626)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437385(CHEMBL2408621)
Affinity DataIC50: 36nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113713(US8637507, C-71 isomer B | US8637507, C-70 isomer ...)
Affinity DataIC50: 36nMT: 2°CAssay Description:The in vitro assay to identify DGAT1 inhibitors uses human DGAT1 enzyme expressed in Sf9 insect cells prepared as microsomes. The reaction was initia...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485394(CHEMBL2059493)
Affinity DataIC50: 53.2nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437379(CHEMBL2408627)
Affinity DataIC50: 54nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113713(US8637507, C-71 isomer B | US8637507, C-70 isomer ...)
Affinity DataIC50: 54nMT: 2°CAssay Description:The in vitro assay to identify DGAT1 inhibitors uses human DGAT1 enzyme expressed in Sf9 insect cells prepared as microsomes. The reaction was initia...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485364(CHEMBL2059474)
Affinity DataIC50: 54.8nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485398(CHEMBL2059384)
Affinity DataIC50: 56.5nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485363(CHEMBL2059473)
Affinity DataIC50: 56.7nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113711(US8637507, C-65)
Affinity DataIC50: 60nMT: 2°CAssay Description:The in vitro assay to identify DGAT1 inhibitors uses human DGAT1 enzyme expressed in Sf9 insect cells prepared as microsomes. The reaction was initia...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437380(CHEMBL2408626)
Affinity DataIC50: 62nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113715(US8637507, C-87)
Affinity DataIC50: 67nMT: 2°CAssay Description:The in vitro assay to identify DGAT1 inhibitors uses human DGAT1 enzyme expressed in Sf9 insect cells prepared as microsomes. The reaction was initia...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485376(CHEMBL2059494)
Affinity DataIC50: 69nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485368(CHEMBL2059481)
Affinity DataIC50: 72.9nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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