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TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113782((10R,13S,17S)-17-hydroxy-13-methyl-10-(4-methylben...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113783((2R,4aS,10aR)-4a-benzyl-2-(chloroethynyl)-1,2,3,4,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM81444(CAS_185453 | NSC_185453 | WB 4101 | WB-4101)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM81444(CAS_185453 | NSC_185453 | WB 4101 | WB-4101)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160165(CHEMBL88272 | RS-17053 | [2-(2-Cyclopropylmethoxy-...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033112(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyla...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM86731(CAS_74191-85-8 | Doxazosin | UK 33,274)
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(3-(3-{3-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-pheny...)
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315763((4bS,7R,8aR)-4b-benzyl-7-hydroxy-7-(prop-1-ynyl)-N...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033111(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM81444(CAS_185453 | NSC_185453 | WB 4101 | WB-4101)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033111(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50124614(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM86731(CAS_74191-85-8 | Doxazosin | UK 33,274)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM86731(CAS_74191-85-8 | Doxazosin | UK 33,274)
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315767((S)-5-allyl-9-(ethynyloxy)-10-methoxy-2,2,4-trimet...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113777((4aS,10aR)-4a-benzyl-7-hydroxy-3,4,4a,9,10,10a-hex...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033111(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315765((S)-5-allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033112(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyla...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160165(CHEMBL88272 | RS-17053 | [2-(2-Cyclopropylmethoxy-...)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160165(CHEMBL88272 | RS-17053 | [2-(2-Cyclopropylmethoxy-...)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315766((S)-9-methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM13775((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033112(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyla...)
Affinity DataKi:  40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315764((S)-5-allyl-9-cyanato-10-methoxy-2,2,4-trimethyl-2...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(3-(3-{3-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-pheny...)
Affinity DataKi:  79nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(3-(3-{3-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-pheny...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049508(5-Bromo-4-methoxy-2-((1S,4R)-2,2,4-trimethyl-6-met...)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049509((R)-5-bromo-2-((2,2-dimethyl-6-methylenecyclohexyl...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049506(5-Bromo-2-((1S,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049497(5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  3.21E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315768(5-bromo-4-methoxy-2-(((1S)-2,2,5-trimethyl-6-methy...)
Affinity DataKi:  4.11E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  11.4nMAssay Description:Displacement of fluoromone from human glucocorticoid receptor LBD assessed as reduction of maximum polarization by fluorescence polarization assay re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetPotassium voltage-gated channel subfamily A member 1(Rat)
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50237249(CHEMBL4076021)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant rat Kv1.1 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily A member 1(Human)
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50237157(CHEMBL4079366)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Kv1.1 (unknown origin) expressed in HEK293 cells by whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50420542(CHEMBL2086965)
Affinity DataIC50:  1.33E+4nMAssay Description:Antagonist activity at wild type AR LBD assessed as inhibition of DHT-induced fluorescent labeled D11-FxxLF recruitment after 2 to 4 hrs by TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily A member 1(Rat)
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50237157(CHEMBL4079366)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant rat Kv(1.1)4 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50420539(CHEMBL2086966)
Affinity DataIC50:  1.59E+4nMAssay Description:Antagonist activity at wild type AR LBD assessed as inhibition of DHT-induced fluorescent labeled D11-FxxLF recruitment after 2 to 4 hrs by TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily A member 1(Rat)
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50237157(CHEMBL4079366)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of recombinant rat Kv1.1 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50420541(CHEMBL2086967)
Affinity DataIC50:  1.79E+4nMAssay Description:Antagonist activity at wild type AR LBD assessed as inhibition of DHT-induced fluorescent labeled D11-FxxLF recruitment after 2 to 4 hrs by TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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